Original Article

International Journal of Impotence Research (2013) 25, 45–50; doi:10.1038/ijir.2012.45; published online 20 December 2012

Effects of Korean ginseng berry extract on sexual function in men with erectile dysfunction: a multicenter, placebo-controlled, double-blind clinical study

Y D Choi1, C W Park2, J Jang2, S H Kim2, H Y Jeon2, W G Kim2, S J Lee2 and W S Chung

  1. 1Department of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul, South Korea
  2. 2R&D Center, Amorepacific Corporation, Gyeonggi-do, South Korea

Correspondence: Dr WS Chung, Department of Urology, Ewha Womans University School of Medicine, Urology Department EU Mok-dong Hospital, 911-1 Mok-dong, Yangcheon-ku, Seoul 158-710, South Korea. E-mail: woochung@ewha.ac.kr

Received 13 April 2012; Revised 8 October 2012; Accepted 26 November 2012
Advance online publication 20 December 2012



Ginseng is beneficial for many aspects of human physiology, including sexual function. In this study, we have evaluated the efficacy and safety of an extract of ginseng berry, which has a ginsenoside profile distinct from other parts of the plant, on sexual function in men with erectile dysfunction. In all, 119 men with mild-to-moderate ED participated in a multicenter, randomized, double-blind, parallel, placebo-controlled clinical study. They were administered 4 tablets of either standardized Korean ginseng berry (SKGB, 350mg ginseng berry extract per tablet), or placebo, daily, for 8 weeks. Efficacy was assessed with the International Index of Erectile Function (IIEF)-15 and premature ejaculation diagnostic tool (PEDT) at the end of the 4th and 8th week. We observed that the total and each of the individual domain scores of IIEF-15 increased from 40.95±7.05 to 46.19±12.69 significantly in the SKGB by the 8th week (P<0.05). The erectile function domain of IIEF changed slightly from 17.17±2.57 to 18.59±5.99 in the SKGB group by the 8th week (P<0.05). In addition, PEDT scores significantly improved from 9.14±4.57 to 7.97±4.4 and 7.53±4.26 in the SKGB group after 4 and 8 weeks of treatment (P<0.05). Safety markers including hormone and lipid in the blood were assessed at the end of the 4th and 8th week and they remained unchanged. Oral administration of the SKGB extract improved all domains of sexual function. It can be used as an alternative medicine to improve sexual life in men with sexual dysfunction.


ejaculation; erection; ginseng berry; sexual function

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