Original Article

International Journal of Impotence Research (2009) 21, 221–227; doi:10.1038/ijir.2009.21; published online 28 May 2009

Effects of vardenafil administration on intravaginal ejaculatory latency time in men with lifelong premature ejaculation

A Aversa1, M Pili1, D Francomano1, R Bruzziches1, E Spera2, G La Pera3 and G Spera1

  1. 1Chair of Internal Medicine, DFM, Sapienza University of Rome, Italy
  2. 2Urology Department, Tor Vergata University of Rome, Italy
  3. 3Azienda Ospedaliera San Camillo, Forlanini, Rome, Italy

Correspondence: Professor A Aversa, Department of Medical Pathophysiology, Sapienza University of Rome, Viale Policlinico 155, 00161 Rome, Italy. E-mail: antonio.aversa@uniroma1.it

Received 16 February 2009; Revised 16 April 2009; Accepted 17 April 2009; Published online 28 May 2009.

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Abstract

Premature ejaculation (PE) is thought to be the most common male sexual dysfunction; however, the prevalence of lifelong (LL)-PE is relatively low. The aim of this study was to investigate the effects of on-demand vardenafil (10mg) to modify the intravaginal ejaculatory latency time (IELT) in men with LL-PE without erectile dysfunction. Forty-two men (18–35 years) were enrolled in a 16-week, double-blind, placebo-controlled, cross-over study. Primary end point was the modification from baseline of IELT assessed by stopwatch technique; secondary end points were post-ejaculatory refractory time (PERT) and variations of scores at the Index of Premature Ejaculation questionnaire. The changes in geometric mean IELT were superior after taking vardenafil (0.6±0.3 vs 4.5±1.1min, P<0.01), compared with placebo (0.7±0.3 vs 0.9±1.0min, ns). PERT dropped significantly after vardenafil (16.7±2.0 vs 4.3±0.9min, P<0.001), compared with placebo (15.3±2.2 vs 15.8±2.3min). Patients who took vardenafil (vs placebo) reported significantly (P<0.01) increased ejaculatory control (6±2 vs 16±2), improved overall sexual satisfaction (7±2 vs 15±1) and distress (4±1 vs 8±1) scores, respectively. Multiple regression analysis (r2=0.86) for IELT by the number of attempts at sexual intercourse showed significant differences between the slopes of lines for placebo and vardenafil (P<0.0001). The most common adverse events for vardenafil (vs placebo) were headache (10 vs 3%), flushing (12 vs 0%) and dyspepsia (10 vs 0%), which tended to disappear over the time. In conclusion, in our study, vardenafil increased IELT and reduced PERT in men with LL-PE. Besides, improvements in confidence, perception of ejaculatory control and overall sexual satisfaction were reported.

Keywords:

phosphodiesterase type-5 inhibitor; IELT; PERT; ejaculatory control; treatment

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