1. ¹Department of Urology, Yonsei University Health System, Seoul, Korea
2. ²Department of Urology, The Catholic University of Korea, Seoul, Korea
3. ³Department of Urology, Keimyung University, Daegu, Korea
4. ⁴Department of Urology, Ulsan University, Seoul, Korea
5. ⁵Department of Urology, Hallym University, Chuncheon, Korea
6. ⁶Department of Urology, Eulji University, Seoul, Korea
7. ⁷Department of Urology, Mizmedi Hospital, Seoul, Korea

Correspondence: Professor BH Chung, Department of Urology, Yongdong Severance Hospital, Yonsei University Health System, Eonju 612, Dogok-dong, Gangnam-gu, Seoul 135-720, Republic of Korea. E-mail: chung646@yuhs.ac

Received 24 October 2008; Revised 11 November 2008; Accepted 15 November 2008; Published online 11 December 2008.

Abstract

The sexuality and the management of benign prostatic hyperplasia (BPH) with alfuzosin (SAMBA) trial evaluated the effect of alfuzosin on sexual function in men treated for BPH using two sexual function scales: male sexual health questionnaire (MSHQ) and international index of erectile function (IIEF-15). A total of 148 patients with BPH were treated with alfuzosin for 24 weeks. The patients were followed at baseline, 4, 12 and 24 weeks after medication with alfuzosin. MSHQ was collected at every visit, whereas Q_max, IPSS and IIEF-15 were checked at baseline and end point. At the end point, Q_max (+4.7 ml s^-1, P<0.01) and IPSS (-5.3, P<0.01) had improved significantly. Alfuzosin also significantly improved the total MSHQ (19.2%, 79.1–94.3, P<0.01) and the MSHQ ejaculatory scores (26.0%, 22.3–28.1, P=<0.01) versus baseline. Alfuzosin for the treatment of patients with BPH is effective in improving sexual function, as well as lower urinary tract symptoms (LUTSs) and quality of life, and is well tolerated.