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Psychopharmacology of male rat sexual behavior: modeling human sexual dysfunctions?

International Journal of Impotence Research volume 18, pages S14–S23 (2006)Cite this article

Abstract

Most of our current understanding of the neurobiology, neuroanatomy and psychopharmacology of sexual behavior and ejaculatory function has been derived from preclinical studies in the rat. When a large population of male rats is tested on sexual activity during a number of successive tests, over time individual rats display a very stable sexual behavior that is either slow, normal or fast as characterized by the number of ejaculations performed. These sexual endophenotypes are postulated as rat counterparts of premature (fast rats) or retarded ejaculation (slow rats). Psychopharmacology in these endophenotypes helps to delineate the underlying mechanisms and pathology. This is illustrated by the effects of serotonergic antidepressants and serotonergic compounds on sexual and ejaculatory behavior of rats. These preclinical studies and models contribute to a better understanding of the neurobiology of ejaculation and boost the development of novel drug targets to treat ejaculatory disorders such as premature and retarded ejaculation.

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Authors and Affiliations

  1. Department of Psychopharmacology, Utrecht Institute for Pharmaceutical Sciences and Rudolf Magnus Institute of Neuroscience, Utrecht University, Utrecht, The Netherlands

    B Olivier, J S W Chan, T Pattij, T R de Jong, R S Oosting, J G Veening & M D Waldinger

  2. Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA

    B Olivier

  3. Department of Anatomy, University Medical Center St Radboud, Nijmegen, The Netherlands

    T Pattij, T R de Jong & J G Veening

  4. Department of Psychiatry and Neurosexology, HagaHospital Leyenburg, The Hague, The Netherlands

    M D Waldinger

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  1. B Olivier
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Correspondence to B Olivier.

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Olivier, B., Chan, J., Pattij, T. et al. Psychopharmacology of male rat sexual behavior: modeling human sexual dysfunctions?. Int J Impot Res 18 (Suppl 1), S14–S23 (2006). https://doi.org/10.1038/sj.ijir.3901330

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