International Journal of Impotence Research
SEARCH     advanced search my account e-alerts subscribe register
Journal home
Advance online publication
Current issue
Archive
Press releases
For authors
For referees
Contact editorial office
About the journal
For librarians
Subscribe
Advertising
naturereprints
Contact Springer Nature
Customer services
Site features
NPG Subject areas
Access material from all our publications in your subject area:
Biotechnology Biotechnology
Cancer Cancer
Chemistry Chemistry
Dentistry Dentistry
Development Development
Drug Discovery Drug Discovery
Earth Sciences Earth Sciences
Evolution & Ecology Evolution & Ecology
Genetics Genetics
Immunology Immunology
Materials Materials Science
Medical Research Medical Research
Microbiology Microbiology
Molecular Cell Biology Molecular Cell Biology
Neuroscience Neuroscience
Pharmacology Pharmacology
Physics Physics
Browse all publications
 
December 1999, Volume 11, Number 6, Pages 319-326
Table of contents    Previous  Abstract  Next   Article  PDF
Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction
R C Rosen1, J C Cappelleri2, M D Smith3, J Lipsky4 and B M Peña5

1University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ

2Biometrics, Pfizer Central Research, Groton, CT

3Biometrics, Pfizer Central Research, Sandwich, Kent, UK

4Marketing Research, Pfizer Pharmaceuticals Group, New York, NY

5Outcomes Research, Pfizer Pharmaceuticals Group, New York, NY, USA

Correspondence to: Raymond C. Rosen PhD, Department of Psychiatry, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854-5635, USA.

Abstract

An abridged five-item version of the 15-item International Index of Erectile Function (IIEF) was developed (IIEF-5) to diagnose the presence and severity of erectile dysfunction (ED). The five items selected were based on ability to identify the presence or absence of ED and on adherence to the National Institute of Health's definition of ED. These items focused on erectile function and intercourse satisfaction. For 1152 men (1036 with ED, 116 controls) analyzed, a receiver operating characteristic curve indicated that the IIEF-5 is an excellent diagnostic test. Based on equal misclassification rates of ED and no ED, a cutoff score of 21 (range of scores, 5-25) discriminated best (sensitivity=0.98, specificity=0.88). ED was classified into five severity levels, ranging from none (22-25) through severe (5-7). Substantial agreement existed between the predicted and 'true' ED classes (weighted kappa=0.82). These data suggest that the IIEF-5 possesses favorable properties for detecting the presence and severity of ED.

Keywords

erectile dysfunction; diagnostic tests; questionnaires; impotence; erectile function; severity

Received 15 January 1999; accepted 21 June 1999
December 1999, Volume 11, Number 6, Pages 319-326
Table of contents    Previous  Abstract  Next   Article  PDF