FIGURE 1
FROM:
Inhibition of destructive autoimmune arthritis in Fc
RIIa transgenic mice by small chemical entities
Geoffrey A Pietersz, Patricia L Mottram, Nicholas C van de Velde, Caroline Tan Sardjono, Sandra Esparon, Paul A Ramsland, Gerard Moloney, Jonathan B Baell, Tom D McCarthy, Barry R Matthews, Maree S Powell and P Mark Hogarth
BACK TO ARTICLEFigure 1.
Target site used for design of small chemical entity (SCE). Solvent-accessible surface views of the Fc
RIIa dimer showing the target site used for design of SCE. (a) Side view with the IgG-binding sites at the top of the FcRIIa dimer; (b) view looking down onto the IgG-binding site and the target site and (c) close-up view of the groove-shaped target site. Key target residues are F132 (yellow), H134 (green) and K120 (red). Other residues lining the groove are: T122, F124, T155, N157, L162 and S164 (dark grey). A prominent IgG-binding site residue is highlighted (Y160), although F132 and K120 also directly participate in binding IgG. (d) Docking of VIB153, (e) docking of VIB384 and (f) docking of VIB113.
