Immunology and Cell Biology - Table 2 for article: Fetal Hox11 expression patterns predict defective target organs: a novel link between developmental biology and autoimmunity

FROM:

Fetal Hox11 expression patterns predict defective target organs: a novel link between developmental biology and autoimmunity

Anna Lonyai, Shohta Kodama, Douglas Burger and Denise L Faustman

	Abnormal cell structures mouse strains			Organ malfunction mouse strains
	NOD	NOD-SCID	Control C57	NOD	NOD-SCID	Control C57
					Deafness^a
Cochlea/ear	Abnormal	Abnormal	Normal	Abnormal	Abnormal	Normal
	100%	100%	<22%	100%	100%	0%
	n=13	n=10	n=8	n=13	n=10	n=8

					Diabetes^b
Pancreas	Abnormal	Abnormal	Normal	Abnormal	Normal	Normal
	100%	100%	0%	>85%	0%	0%
	n=15	n=18	n=18	n=56	n=15	n=15

					Salivary flow^c
Salivary gland	Abnormal	Abnormal	Normal	Abnormal	Normal	Normal
	100%	100%	0	>90%	0%	0%
	n=8	n=9	n=8	n=5	n=5	n=14

Tongue	Abnormal	Abnormal	Normal	NA	NA	NA
	100%	100%	100%
	n=6	n=2	n=4

Abbreviation: NA, not applicable.

Control mice in this study were C57BL/6 mice, sex and age matched to the NOD and NOD-SCID.

All cell structure comparisons in this table represent mice at 5–8 weeks of age.

^a Hearing was monitored by ABR as described in the Methods at 5–8 weeks of age.

^b Incidence of diabetes was monitored in female mice from about 15 weeks of age until diabetes, typically at 25 weeks of age.

^c Salivary flow was monitored in mice after 12 weeks of age by the pilocarpine salivary flow test.