Immunology and Cell Biology - Table 1 for article: Quantitative and qualitative approaches to GOD: the first 10 years of the clonal selection theory

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Quantitative and qualitative approaches to GOD: the first 10 years of the clonal selection theory

Margaret A Jordan and Alan G Baxter

Table 1. Frequencies (f) of antibody producing cells of two different specificities, S1 and S2, total numbers of cells examined and the observed and expected numbers of double producers

Reference	f(S1)	f(S2)	Cell number
			Total	Exp	Obs	P
Nossal¹⁸	27/172	20/154	47	1.0	0	NS
Nossal and Lederberg¹⁹	33/228	29/228	456	8.76	0	<0.003
Mäkelä and Nossal²⁰	155/1333	173/1333	1333	36.6	4	<0.0001
Nossal and Mäkelä²¹	362/1690	202/1690	1690	43.3	19	<0.0005
Nossal and Mäkelä²²	422/1729	172/1729	1729	42.0	8	<0.0001
Nossal and Mäkelä²²	140/1729	172/1729	1729	13.9	10	NS
Mäkelä²³	56/717	35/717	717	2.7	0	NS
Attardi et al. ²⁴	47/925	27/925	925	1.37	21	<0.0001
Attardi et al. ²⁵	19/280	11/280	280	0.75	5	<0.005
Attardi et al. ²⁵	19/280	14/280	280	0.75	2	NS
Attardi et al. ²⁵	11/280	14/280	280	0.75	3	<0.01

Abbreviation: NS, not significant.

Significance calculated by ² goodness-of-fit test of observed and expected numbers of double and nonproducers with 1 degree of freedom. Where more than one combination was studied pair-wise calculations have been made to aid comparison.

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TABLE 1

Quantitative and qualitative approaches to GOD: the first 10 years of the clonal selection theory

Table 1. Frequencies (f) of antibody producing cells of two different specificities, S1 and S2, total numbers of cells examined and the observed and expected numbers of double producers