Immunology and Cell Biology

TABLE 1

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Axon growth and guidance genes identify T-dependent germinal centre B cells

Di Yu, Matthew C Cook, Dong-Mi Shin, Diego G Silva, Jennifer Marshall, Kai-Michael Toellner, Wendy L Havran, Pico Caroni, Michael P Cooke, Herbert C Morse, Ian CM MacLennan, Christopher C Goodnow and Carola G Vinuesa

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Table 1. Neurite growth genes differentially expressed in TD GC B cells

Figure and tables index
Gene symbol Expression pattern Subcellular localization Function in neurons/CNS Other functions References
Plxnb2 (Plexin B2) Developing nervous systemCell surfaceNeurite growth and guidanceNot known 23, 32, 47, 57
Basp1 Adult central and peripheral nervous system; early embryonic developing tissuesPlasmalemmal microdomains (rafts)Neurite sprouting, synaptic plasiticity, axon repair after axotomy, cell adhesion and spreadingNot known 20, 21, 42
Nelf Embryonic developing nervous systemCell surfaceAxonal projection guidance and neuronal migrationNot known 58, 59
Shh Embryonic developing nervous system and limbs; adult organsSecreted, diffuses; endosomes and lysosomesAxon guidance; regulation of CNS polarity, neural stem cell proliferation, neuronal and glial cell survivalRegulates morphology of many tissues 60, 61
Tcp1 Wide tissue expressionCytoplasm, particularly at the leading edge of growth cones in neuritic processesAxonal growthFolding of cytoskeletal proteins 62, 63, 64
Sc4mol BrainCytoplasmRepair after axotomyNot known 65
Sult4a1 Selectively in the brainCytoplasmRelated to schizophreniaNot known 66, 67, 68
Marcks Many tissues, particularly in the brainPlasmalemmal microdomains (rafts)Maintenance of dendritic spinsCellular migration, adhesion 43
Ligatin Mainly in the central nervous systemCytoplasm, particularly in dendritesNeuroplasticity, cell–cell interactionsNot known 69
Scl6a1 Neurons and glial cells in the brainProcesses and nerve endingsNeurotransmission regulationNot known 70
Figure and tables index
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