Immunology and Cell Biology

FIGURE 3

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Mycobacterium tuberculosis secretory proteins CFP-10, ESAT-6 and the CFP10:ESAT6 complex inhibit lipopolysaccharide-induced NF-kappaB transactivation by downregulation of reactive oxidative species (ROS) production

Niladri Ganguly, Pham H Giang, Chitra Gupta, Sandip K Basu, Imran Siddiqui, Dinakar M Salunke and Pawan Sharma

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Figure 3.

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The inhibition of reactive oxidative species (ROS) production is specific for ESAT-6 family proteins. RAW264.7 macrophages were treated with different doses of two non-ESAT-6 family proteins, CFP-21 and Antigen 85B. The graph shows the generation of ROS as measured by H2DCFDA oxidation upon stimulation with 5, 10 and 20 mug ml-1 of CFP-21 and Antigen-85B for 5 min at 37 °C. The data are represented as meanplusminuss.d. of three independent experiments.

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