Immunology and Cell Biology

FIGURE 4

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TGFbold beta is responsible for skin tumour infiltration by macrophages enabling the tumours to escape immune destruction

Scott N Byrne, Matthew C Knox and Gary M Halliday

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Figure 4.

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Macrophages are the dominant phagocytic cells infiltrating progressing skin tumours. (a) Injected intravenously 18 h prior to tumour removal and analysis by four-colour flow cytometry. The phenotype of the cells that had taken up beads were confirmed as either CD11c+CD11b+MHC IIhigh DC (bold histogram) or CD11c-CD11b+MHC II+ TAM (shaded histogram). Progressor tumour dot plots only are displayed as regressor dot plots looked similar. (b) Significantly more beads were taken up by any type of cell (percentage of total) within regressor (solid bar) compared to progressor (open bar) tumours (n=7). (c) Analysis of the percentage of each APC subset (DC in solid bars statistically compared to TAM in the open bar) that had taken up beads (n=7). In all cases mean+s.e.m. shown. * P<0.05. APC, antigen-presenting cell; DC, dendritic cells; TAM, tumour-associated macrophages.

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