Review
Immunology and Cell Biology (2007) 85, 274–279; doi:10.1038/sj.icb.7100053; published online 10 April 2007
Mathematical models of cytotoxic T-lymphocyte killing
Roland R Regoes1, Andrew Yates2 and Rustom Antia3
- 1Institute of Integrative Biology, ETH Zurich, Zurich, Switzerland
- 2Department of Biology, Emory University, Atlanta, GA, USA
- 3Department of Biology, Emory University, Atlanta, GA, USA
Correspondence: Dr R Antia, Department of Biology, Emory University, Atlanta, GA 30322, USA. E-mail: rantia@emory.edu
Received 14 February 2007; Accepted 16 February 2007; Published online 10 April 2007.
Abstract
By killing infected host cells, cytotoxic T lymphocytes (CTL) mediate an important defense mechanism against viruses and other intracellular pathogens. Quantitative aspects of this killing process have been studied for several decades in vitro. More recently, methods have been developed to measure the timescales of CTL killing in vivo. Here, we review the estimates of kinetic rates involved in CTL killing which were obtained in these studies, and elaborate on the differences between them.
Keywords:
cytotoxic T cell, estimation of killing rates, mathematical modeling
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