Review
Immunology and Cell Biology (2007) 85, 280–286; doi:10.1038/sj.icb.7100050; published online 20 March 2007
Quantifying HTLV-I dynamics
Becca Asquith1 and Charles R M Bangham1
1Department of Immunology, Imperial College London, London, UK
Correspondence: Dr B Asquith, Department of Immunology, Imperial College, Norfolk Place, London W2 1PG, UK. E-mail: b.asquith@imperial.ac.uk
Received 6 February 2007; Accepted 12 February 2007; Published online 20 March 2007.
Abstract
Despite significant advances in our understanding of the immune response to persistent viruses like human T-cell lymphotropic virus type I (HTLV-I), many important questions remain unanswered. Mathematical modelling enables us to interpret and synthesise diverse experimental data in new ways and thus can contribute to our understanding. Here, we review recent advances in mathematical modelling of HTLV-I infection and illustrate how mathematics has enabled us to identify factors that determine an individual's viral burden and risk of developing HTLV-I-associated diseases.
Keywords:
HTLV-1, HIV-1, mathematical model, kinetics, cytotoxic T lymphocytes
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