Immunology and Cell Biology

FIGURE 2

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Three-dimensional structures of carbohydrate determinants of Lewis system antigens: Implications for effective antibody targeting of cancer

Elizabeth Yuriev, William Farrugia, Andrew M Scott and Paul A Ramsland

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Figure 2.

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Antibody-bound conformations of Lewis carbohydrate determinants. The hexose rings of the GlcNAc residues were used to overlay the various ligands, namely: the Ley tetrasaccharide from the hu3S193 Fab complex (black; 1S3K); the Ley nonoate methyl ester (Non) from the BR96 Fab complex (black dashed lines; 1CLY); and, the Lex (beta-O-methyl glycoside) trisaccharide from the 291-2G3-A Fab complex (grey; 1UZ8). This figure was prepared using the MOLMOL program53

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