Immunology and Cell Biology

FIGURE 3

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Inulin-derived adjuvants efficiently promote both Th1 and Th2 immune responses

Diego G Silva, Peter D Cooper and Nikolai Petrovsky

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Figure 3.

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Gamma inulin (gamma-IN) is an effective malaria vaccine adjuvant. Mice (C57Bl/6) were immunized with Plasmodium falciparum merozoite surface protein (MSP) 5 (25 microg per mouse) plus either gamma-IN (500 microg per mouse), Freund's complete adjuvant (FCA) (v/v) or PBS. Fourteen days after the second immunization, gamma-IN treated mice had equivalent titres of MSP 5-specific IgG, IgG1, IgG2a and IgG2b to FCA treated mice. filled square, gamma-IN + MSP 5; square with thin vertical lines, FCA + MSP 5; square, PBS + MSP 5.

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