Immunology and Cell Biology

FIGURE 6

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FGF signal transduction in PC12 cells: Comparison of the responses induced by endogenous and chimeric receptors

Erik D Foehr, Simona Raffioni, Ritsuko Fuji and Ralph A Bradshaw

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Figure 6.

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Formation of a SOS/Grb2/FRS2 complex in response to PFR1 stimulation. Rat phaeochromocytoma (PC12) cells expressing PFR1 were incubated at 37 °C with 30 ng/mL platelet-derived growth factor (PDGF) for 10 min. One thousand mug of lysate was incubated with anti-SOS antisera (a) or p13suc agarose (b), precipitates collected and subjected to 7.5% SDS-PAGE and immunoblotting. The top panels were probed with anti-SOS antibodies, the middle with anti-phosphotyrosine antibody, and the bottom with anti-Grb2 antibody.

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