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TRANSPLANTATION IMMUNOBIOLOGY
- Focus issue:
- March 2009 Volume 87, No 3
The two greatest challenges facing the widespread use of transplanted organs are availability of suitable organs and prevention of graft rejection by the host's immune system. This special feature on transplantation immunobiology addresses the two approaches to overcome these problems: obtaining transplantable organs from animals (usually pigs) rather than humans (known as xenotransplantation), and developing clever ways of specifically suppressing the recipient's immune system (regulatory T cells are proving relevant) rather than using current, non-specific immunosuppressive drugs that have considerable side effects. The accompanying web focus delves into the various techniques currently available for preventing xenotransplant rejection by modifying the graft, and explores approaches aimed at developing immunological tolerance to transplanted tissues in graft recipients.
Image reproduced from Kidney International 74, 14–21 (2008).
Library
Progress and prospects: genetic engineering in xenotransplantation
S Le Bas-Bernardet, I Anegon and G Blancho
Gene Therapy 15, 1247–1256 | doi:10.1038/gt.2008.119
Characteristics of protein-carbohydrate interactions as a basis for developing novel carbohydrate-based antirejection therapies
Lawrence R Shiow, David W Roadcap, Kenneth Paris, Susan R Watson, Irina L Grigorova, Tonya Lebet, Jinping An, Ying Xu, Craig N Jenne, Niko Föger, Ricardo U Sorensen, Christopher C Goodnow, James E Bear, Jennifer M Puck and Jason G Cyster
Immunology & Cell Biology 83, 694–708 | doi:10.1111/j.1440-1711.2005.01373.x
Xenotransplantation: Where are we in 2008?
B Sprangers, M Waer and A D Billiau
Kidney International 74, 14–21 | doi:10.1038/ki.2008.135
Suppression of cytotoxic and proliferative xenogeneic T-cell responses by transgenic expression of indoleamine 2,3-dioxygenase
Janet Lye-Keng Wee, Dale Christiansen, Yu-Qin Li, William Boyle and Mauro S Sandrin
Immunology & Cell Biology 86, 460–465 | doi:10.1038/icb.2008.8
Marked prolongation of porcine renal xenograft survival in baboons through the use of α1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue
Kazuhiko Yamada, Koji Yazawa, Akira Shimizu, Takehiro Iwanaga, Yosuke Hisashi, Matthew Nuhn, Patricia O'Malley, Shuji Nobori, Parsia A Vagefi, Clive Patience, Jay Fishman, David K C Cooper, Robert J Hawley, Julia Greenstein, Henk-Jan Schuurman, Michel Awwad, Megan Sykes and David H Sachs
Nature Medicine 11, 32–34 | doi:10.1038/nm1172
Abstract | Full Text | PDF (253KB) | Supplementary information
Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts
Jordi C Ochando, Chiho Homma, Yu Yang, Andres Hidalgo, Alexandre Garin, Frank Tacke, Veronique Angeli, Yansui Li, Peter Boros, Yaozhong Ding, Rolf Jessberger , Giorgio Trinchieri, Sergio A Lira, Gwendalyn J Randolph and Jonathan S Bromberg
Nature Immunology 7, 652–662 | doi:10.1038/ni1333
Abstract | Full Text | PDF (898KB) | Supplementary information
Tolerance can be infectious
Herman Waldmann
Nature Immunology 9, 1001–1003 | doi:10.1038/ni0908-1001
The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance FREE
Alejandro Villagra, Fengdong Cheng, Hong-Wei Wang, Ildelfonso Suarez, Michelle Glozak, Michelle Maurin, Danny Nguyen, Kenneth L Wright, Peter W Atadja, Kapil Bhalla, Javier Pinilla-Ibarz, Edward Seto and Eduardo M Sotomayor
Nature Immunology 10, 92–100 | doi:10.1038/ni.1673
Abstract | Full Text | PDF (729KB) | Supplementary information
Tolerance strategies for stem-cell-based therapies
Ann P Chidgey, Daniel Layton, Alan Trounson and Richard L Boyd
Nature 453, 330–337 | doi:10.1038/nature07041
Prevention of acute and chronic allograft rejection with CD4+CD25+Foxp3+ regulatory T lymphocytes
Olivier Joffre, Thibault Santolaria, Denis Calise, Talal Al Saati, Denis Hudrisier, Paola Romagnoli and Joost P M van Meerwijk
Nature Medicine 14, 88–92 | doi:10.1038/nm1688
First paragraph | Full Text | PDF (587KB) | Supplementary information
The Foxp3+ regulatory T cell: a jack of all trades, master of regulation
Qizhi Tang and Jeffrey A Bluestone
Nature Immunology 9, 239–244 | doi:10.1038/ni1572
Distribution of the αGal- and the non-αGal T-antigens in the pig kidney: potential targets for rejection in pig-to-man xenotransplantation
Svend Kirkeby and Hanne B Mikkelsen
Immunology & Cell Biology 86, 363–371 | doi:10.1038/icb.2008.1
Transient transmission of porcine endogenous retrovirus to fetal lambs after pig islet tissue xenotransplantation
Sarah K Popp, David A Mann, Peter J Milburn, Adrian J Gibbs, Peter J McCullagh, James Dennis Wilson, Ralf R Tönjes and Charmaine J Simeonovic
Immunology & Cell Biology 85, 238–248 | doi:10.1038/sj.icb.7100028
B lymphocyte-directed immunotherapy promotes long-term islet allograft survival in nonhuman primates
Chengyang Liu, Hooman Noorchashm, Jennifer A Sutter, Mina Naji, Eline Luning Prak, Jean Boyer, Taryn Green, Michael R Rickels, John E Tomaszewski, Brigitte Koeberlein, Zhonglin Wang, Michelle E Paessler, Ergun Velidedeoglu, Susan Y Rostami, Ming Yu, Clyde F Barker and Ali Naji
Nature Medicine 13, 1295–1298 | doi:10.1038/nm1673
Abstract | Full Text | PDF (393KB) | Supplementary information
