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LYMPHOCYTES RETURN HOME
- Focus issue:
- January 2009 Volume 87, No 1
Initially, it was thought that primary lymphoid organs exclusively produce cells and that once cells left, few would re-enter. However, recent data have shown that numerous cell types can return to the thymus. This focus brings together a collection of articles representing our current understanding of the field. The accompanying special feature deals with the nature and possible functional consequences of cellular traffic, both lymphoid and myeloid, back to the primary lymphoid organs.
Library
Immunodeficiency: when T cells are stuck at home
Kristin A Hogquist
Nature Immunology 9, 1207–1208 | doi:10.1038/ni1108-1207
The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency
Lawrence R Shiow, David W Roadcap, Kenneth Paris, Susan R Watson, Irina L Grigorova, Tonya Lebet, Jinping An, Ying Xu, Craig N Jenne, Niko Föger, Ricardo U Sorensen, Christopher C Goodnow, James E Bear, Jennifer M Puck and Jason G Cyster
Nature Immunology 9, 1307–1315 | doi:10.1038/ni.1662
Orchestrating the orchestrators: chemokines in control of T cell traffic
Shannon K Bromley, Thorsten R Mempel and Andrew D Luster
Nature Immunology 9, 970–980 | doi:10.1038/ni.f.213
T-cell migration: Kruppeled T cells move again FREE
Kristin A Hogquist, Michael A Weinreich and Stephen C Jameson
Immunology and Cell Biology 86, 297–298 | doi:10.1038/icb.2008.20
Perivascular clusters of dendritic cells provide critical survival signals to B cells in bone marrow niches
Anita Sapoznikov, Yael Pewzner-Jung, Vyacheslav Kalchenko, Rita Krauthgamer, Idit Shachar and Steffen Jung
Nature Immunology 9, 388–395 | doi:10.1038/ni1571
Abstract | Full Text | PDF (754KB) | Supplementary information
Transcription factor KLF2 regulates the migration of naive T cells by restricting chemokine receptor expression patterns
Eric Sebzda, Zhiying Zou, John S Lee, Tao Wang and Mark L Kahn
Nature Immunology 9, 292–300 | doi:10.1038/ni1565
Abstract | Full Text | PDF (412KB) | Supplementary information
The sphingosine 1-phosphate receptor 1 causes tissue retention by inhibiting the entry of peripheral tissue T lymphocytes into afferent lymphatics
Levi G Ledgerwood, Girdhari Lal, Nan Zhang, Alexandre Garin, Steven J Esses, Florent Ginhoux, Miriam Merad, Helene Peche, Sergio A Lira, Yaozhong Ding, Yu Yang, Xingxuan He, Edward H Schuchman, Maria L Allende, Jordi C Ochando and Jonathan S Bromberg
Nature Immunology 9, 42–53 | doi:10.1038/ni1534
Abstract | Full Text | PDF (579KB) | Supplementary information
Finding a way out: lymphocyte egress from lymphoid organs
Susan R Schwab and Jason G Cyste
Nature Immunology 8, 1295–1301 | doi:10.1038/ni1545
Interaction of the selectin ligand PSGL-1 with chemokines CCL21 and CCL19 facilitates efficient homing of T cells to secondary lymphoid organs
Krystle M Veerman, Michael J Williams, Kenji Uchimura, Mark S Singer, Jasmeen S Merzaban, Silvia Naus, Douglas A Carlow, Philip Owen, Jesús Rivera-Nieves, Steven D Rosen and Hermann J Ziltener
Nature Immunology 8, 532–539 | doi:10.1038/ni1456
Abstract | Full Text | PDF (633KB) | Supplementary information
Clonal deletion of thymocytes by circulating dendritic cells homing to the thymus
Roberto Bonasio, M Lucila Scimone, Patrick Schaerli, Nir Grabie, Andrew H Lichtman and Ulrich H von Andrian
Nature Immunology 7, 1092–1100 | doi:10.1038/ni1385
Abstract | Full Text | PDF (465KB) | Supplementary information
Kruppel-like factor 2 regulates thymocyte and T-cell migration FREE
Corey M. Carlson, Bart T. Endrizzi, Jinghai Wu, Xiaojie Ding, Michael A. Weinreich, Elizabeth R. Walsh, Maqsood A. Wani, Jerry B. Lingrel, Kristin A. Hogquist and Stephen C. Jameson
Nature 442, 299–302 | doi:10.1038/nature04882
First paragraph | Full Text | PDF (482KB) | Supplementary information
CD8+ recent thymic emigrants home to and efficiently repopulate the small intestine epithelium
Tracy L Staton, Aida Habtezion, Monte M Winslow, Tohru Sato, Paul E Love and Eugene C Butcher
Nature Immunology 7, 482–488 | doi:10.1038/ni1319
Abstract | Full Text | PDF (395KB) | Supplementary information
Thymic microenvironments for T cell differentiation and selection
Ena Ladi, Xinye Yin, Tatyana Chtanova and Ellen A Robey
Nature Immunology 7, 338–343 | doi:10.1038/ni1323
Abstract | Full Text | PDF (310KB) | Supplementary information
The sense of place in the immune system
Michael D Cahalan and George A Gutman
Nature Immunology 7, 329–332 | doi:10.1038/ni0406-329
Abstract | Full Text | PDF (116KB) | Supplementary information
Journey through the thymus: stromal guides for T-cell development and selection
Yousuke Takahama
Nature Reviews Immunology 6, 127–135 | doi:10.1038/nri1781
