Original Article

Hypertension Research (2007) 30, 213–218; doi:10.1291/hypres.30.213

NADH Dehydrogenase Subunit-2 237 Leu/Met Polymorphism Modifies the Effects of Alcohol Consumption on Risk for Hypertension in Middle-Aged Japanese Men

Akatsuki Kokaze1, Mamoru Ishikawa1,2, Naomi Matsunaga1, Masao Yoshida1, Masao Satoh3, Koji Teruya4, Yumi Masuda1, Rie Honmyo1, Yoshiko Uchida1 and Yutaka Takashima1

  1. 1Department of Public Health, Kyorin University School of Medicine, Mitaka, Japan
  2. 2Mito Red Cross Hospital, Mito, Japan
  3. 3Department of Allergy and Immunology, Saitama Medical School, Saitama, Japan
  4. 4Department of Public Health, Kyorin University School of Health Sciences, Hachioji, Japan

Correspondence: Akatsuki Kokaze, M.D., Ph.D., Department of Public Health, Kyorin University School of Medicine, 6-20-2, Shinkawa, Mitaka 181-8611, Japan. E-mail: dawn@kyorin-u.ac.jp

Received 3 March 2006; Accepted 16 November 2006.

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Abstract

NADH dehydrogenase subunit-2 237 leucine/methionine (ND2-237 Leu/Met) polymorphism is associated with longevity in the Japanese population, and the ND2-237Met genotype may exert antiatherogenic effects. To investigate whether ND2-237 Leu/Met polymorphism is associated with risk of hypertension, we conducted a cross-sectional study of 398 Japanese male subjects. The frequency of hypertension was significantly higher in ND2-237Leu genotypic men than in ND2-237Met genotypic men. On analysis of covariance, the interaction between ND2-237 Leu/Met polymorphism and habitual drinking was significantly associated with both systolic blood pressure and diastolic blood pressure. Multiple logistic regression analysis revealed that the ND2-237Met genotype, particularly in younger subjects (age <60 years), had a lower odds ratio for hypertension than the ND2-237Leu genotype. Moreover, the association of ND2-237 Leu/Met polymorphism with hypertension may depend on the frequency of alcohol consumption. The odds ratio for hypertension was significantly higher in daily drinkers with ND2-237Leu when compared with non- or ex-drinkers with ND2-237Leu. However, the association between the ND2-237Met genotype and hypertension may not depend on the frequency of alcohol consumption. The present results suggest that ND2-237 Leu/Met polymorphism is associated with hypertension and that modification of hypertension risk is dependent on alcohol consumption in middle-aged Japanese men.

Keywords:

hypertension, NADH dehydrogenase, habitual drinking, longevity, personalized preventive medicine

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References

  1. Atzmon G, Schechter C, Greiner W, Davidson D, Rennert G, Barzilai N: Clinical phenotype of families with longevity. J Am Geriatr Soc 2004; 52: 274–277. | Article | PubMed |
  2. Franco OH, Peeters A, Bonneux L, de Laet C: Blood pressure in adulthood and life expectancy with cardiovascular disease in men and women. Life Course Analysis. Hypertension 2005; 46: 280–286. | Article | PubMed | ChemPort |
  3. Tanaka M, Gong JS, Zhang J, Yoneda M, Yagi K: Mitochondrial genotype associated with longevity. Lancet 1998; 351: 185–186. | Article | PubMed | ISI | ChemPort |
  4. Mukae S, Aoki S, Itoh S, et al: Mitochondrial 5178A/C genotype is associated with acute myocardial infarction. Circ J 2003; 67: 16–20. | Article | PubMed | ChemPort |
  5. Takagi K, Yamada Y, Gong JS, Sone T, Yokota M, Tanaka M: Association of a 5178Cright arrowA (Leu237Met) polymorphism in the mitochondrial DNA with a low prevalence of myocardial infarction in Japanese individuals. Atherosclerosis 2004; 175: 281–286. | Article | PubMed | ChemPort |
  6. Ohkubo R, Nakagawa M, Ikeda K, et al: Cerebrovascular disorders and genetic polymorphisms: mitochondrial DNA5178C is predominant in cerebrovascular disorders. J Neurol Sci 2002; 198: 31–35. | Article | PubMed | ChemPort |
  7. Kokaze A, Ishikawa M, Matsunaga N, et al: Longevity-associated mitochondrial DNA 5178 A/C polymorphism and blood pressure in the Japanese population. J Hum Hypertens 2004; 18: 41–45. | Article | PubMed | ChemPort |
  8. Kokaze A, Ishikawa M, Matsunaga N, et al: Association of the mitochondrial DNA 5178 A/C polymorphism with serum lipid levels in the Japanese population. Hum Genet 2001; 109: 521–525. | Article | PubMed | ChemPort |
  9. Kokaze A, Ishikawa M, Matsunaga N, et al: Longevity-associated mitochondrial DNA 5178 A/C polymorphism modulates effects of daily drinking and cigarette consumption on serum triglyceride levels in middle-aged Japanese men. Exp Gerontol 2003; 38: 1071–1076. | Article | PubMed | ChemPort |
  10. Kokaze A, Ishikawa M, Matsunaga N, et al: Longevity-associated mitochondrial DNA 5178 C/A polymorphism is associated with fasting plasma glucose levels and glucose tolerance in Japanese men. Mitochondrion 2005; 5: 418–425. | Article | PubMed | ChemPort |
  11. Kokaze A, Ishikawa M, Matsunaga N, et al: Longevity-associated NADH dehydrogenase subunit-2 237 Leu/Met polymorphism influences the effects of alcohol consumption on serum uric acid levels in nonobese Japanese men. J Hum Genet 2006; 51: 765–771. | Article | PubMed | ChemPort |
  12. Jarrett RJ, Keen H, McCartney M, et al: Glucose tolerance and blood pressure in two population samples: their relation to diabetes mellitus and hypertension. Int J Epidemiol 1978; 7: 15–24. | Article | PubMed | ChemPort |
  13. Marre M, Berrut G, Bouhanick B: Hypertension and diabetes mellitus. Biomed Pharmacother 1993; 47: 61–66. | Article | PubMed | ChemPort |
  14. Wang D, Taniyama M, Suzuki Y, Katagiri T, Ban Y: Association of the mitochondrial DNA 5178 A/C polymorphism with maternal inheritance and onset of type 2 diabetes in Japanese patients. Exp Clin Endocrinol Diabetes 2001; 109: 361–364. | Article | PubMed | ChemPort |
  15. Matsunaga H, Tanaka Y, Tanaka M, et al: Antiatherogenic mitochondrial genotype in patients with type 2 diabetes. Diabetes Care 2001; 24: 500–503. | Article | PubMed | ChemPort |
  16. Kokaze A: Genetic epidemiological studies of longevity-associated mitochondrial DNA 5178 C/A polymorphism. Environ Health Prev Med; 2005; 10: 319–323. | Article | ChemPort |
  17. Levine RL, Moskovitz J, Stadtman ER: Oxidation of methionine in proteins: roles in antioxidant defense and cellular regulation. IUBMB Life 2000; 50: 301–307. | Article | PubMed | ISI | ChemPort |
  18. Lenaz G, Bovina C, D'Aurelio M, et al: Role of mitochondria in oxidative stress and aging. Ann N Y Acad Sci 2002; 959: 199–213. | PubMed | ChemPort |
  19. Yasunari K, Maeda K, Nakamura M, Watanabe T, Yoshikawa J: Benidipine, a long-acting calcium channel blocker, inhibits oxidative stress in polymorphonuclear cells in patients with essential hypertension. Hypertens Res 2005; 28: 107–112. | Article | PubMed | ChemPort |
  20. Maeda K, Yasunari K, Watanabe T, Nakamura M: Oxidative stress by peripheral blood mononuclear cells is increased in hypertensives with an extreme-dipper pattern and/or morning surge in blood pressure. Hypertens Res 2005; 28: 755–761. | Article | PubMed | ISI | ChemPort |
  21. Kokaze A, Yoshida M, Ishikawa M, et al: Longevity-associated mitochondrial DNA 5178 A/C polymorphism is associated with intraocular pressure in Japanese men. Clin Experiment Ophthalmol 2004; 32: 131–136. | Article | PubMed |
  22. Bailey SM, Pietsch EC, Cunningham CC: Ethanol stimulates the production of reactive oxygen species at mitochondrial complex I and III. Free Radic Biol Med 1999; 27: 891–900. | Article | PubMed | ChemPort |
  23. Bailey SM, Cunningham CC: Contribution of mitochondria to oxidative stress associated with alcoholic liver disease. Free Radic Biol Med 2002; 32: 11–16. | Article | PubMed | ISI | ChemPort |
  24. Katsuya T, Baba S, Ishikawa K, et al: Epsilon 4 allele of apolipoprotein E gene associates with lower blood pressure in young Japanese subjects: the Suita Study. J Hypertens 2002; 20: 2017–2021. | Article | PubMed | ChemPort |
  25. Shirakawa T, Ozono R, Kasagi F, Oshima T, Kamada N, Kambe M: Differential impact of family history on age-associated increase in the prevalence of hypertension and diabetes in male Japanese workers. Hypertens Res 2006; 29: 81–87. | Article | PubMed |
  26. Ejima Y, Hasegawa Y, Sanada S, et al: Characteristics of young-onset hypertension identified by targeted screening performed at a university health check-up. Hypertens Res 2006; 29: 261–267. | Article | PubMed |
  27. Tamaki S, Nakamura Y, Tabara Y, et al: Combined analysis of polymorphisms in angiotensinogen and adducin genes and their effects on hypertension in a Japanese sample: the Shigaraki Study. Hypertens Res 2005; 28: 645–650. | Article | PubMed | ChemPort |
  28. Yamamoto M, Jin JJ, Wu Z, et al: Interaction between serotonin 2A receptor and endothelin-1 variants in association with hypertension in Japanese. Hypertens Res 2006; 29: 227–232. | Article | PubMed | ChemPort |

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