Original Article

Hypertension Research (2005) 28, 651–655; doi:10.1291/hypres.28.651

Do Eicosapentaenoic Acid Supplements Attenuate Age-Related Increases in Arterial Stiffness in Patients with Dyslipidemia?: A Preliminary Study

Hirofumi Tomiyama1, Kenji Takazawa1, Shin-ichi Osa2, Ken-ichi Hirose2, Akio Hirai3, Toshiro Iketani4, Masami Monden5, Kyo Sanoyama6 and Akira Yamashina1

  1. 1Second Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan
  2. 2Tokyo Medical University Kasumigaura Hospital, Ibaraki, Japan
  3. 3Kosei-cho Hospital, Tokyo, Japan
  4. 4Iketani Clinic, Tokyo, Japan
  5. 5St. Luke's International Hospital Tokyo, Tokyo, Japan
  6. 6Sanoyama Clinic, Tokyo, Japan

Correspondence: Akira Yamashina, M.D., Second Department of Internal Medicine, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Shinjukuku, Tokyo 160-0023, Japan. E-mail: akyam@tokyo-med.ac.jp

Received 18 February 2005; Accepted 13 June 2005.

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Abstract

The present study was conducted to examine the effect of eicosapentaenoic acid supplements on pulse wave velocity (PWV) in patients with dyslipidemia as a prospective open-labeled study. Eicosapentaenoic acid supplements (1,800 mg/day) were prescribed to 40 patients, and diet therapy in consultation with a nutritionist was conducted in 44 patients as a control group. These interventions were continued for 12 months, and PWV and blood examinations were performed at the start and end of these interventions. PWV increased in the control group but not in the eicosapentaenoic acid group. After adjustment for age, gender, the initial PWV, and the changes in mean blood pressure during the study period, a general linear model univariate analysis post hoc comparison demonstrated that the change in PWV during the period of study was significantly larger in the control group (42plusminus20 cm/s) than in the eicosapentaenoic acid group (-9plusminus19 cm/s) (p<0.05). Thus, this preliminary study suggested that eicosapentaenoic acid supplements attenuate age-related increases in arterial stiffness in patients with dyslipidemia. A further study with a larger number of subjects is proposed to confirm this beneficial effect of eicosapentaenoic acid supplements on arterial stiffness.

Keywords:

arterial stiffness, dyslipidemia, eicosapentaenoic acid

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References

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