In need of more space

David Bradley

Figure 1 | Click chemistry.

In the 'click chemistry' strategy, reactive chemical building blocks are designed to 'click' together selectively and covalently. The different reactive building blocks that are used are chemically complementary to each other, yet are mutually independent in all other functionalities. Each component can anchor itself to one of the binding positions in an enzyme's active site and, as they are in close proximity, they can snap together in a fast reaction to form a single molecule.