As illustrated in this special issue, quantitative genetics is a dynamic and expanding field. New developments in methodologies (molecular and statistical) coupled with new theoretical approaches (such as associative effects models where members of a group influence the trait value of a focal individual) have significant implications for evolutionary biologists, breeders, and human geneticists. Papers highlight recent findings on the genetic architecture of traits, the limitations of genomic selection, the nature of selection on QTLs in natural populations, the behaviour of additive variance in fitness, and the stability of G matrices.