ADVANCE ONLINE PUBLICATION
The latest research papers, published online ahead of print. These online versions are definitive and may be cited using the digital object identifier (DOI).
About advance online publication
May 1 2008 |
April 24 2008 |
April 17 2008 |
April 10 2008 |
April 3 2008 |
March 27 2008 |
March 20 2008 |
March 13 2008 |
March 6 2008 |
February 21 2008
May 8 2008
News and Commentary
A new player in gene therapy for pain? FREE
M Pohl and D J Fink
Gene Ther advance online publication, May 8, 2008; doi:10.1038/gt.2008.80
Original Articles
Enhancement of CD4+ T-cell help reverses the doxorubicin-induced suppression of antigen-specific immune responses in vaccinated mice
D Kim, A Monie, Y-C Tsai, L He, M-C Wang, C-F Hung and T-C Wu
Gene Ther advance online publication, May 8, 2008; doi:10.1038/gt.2008.79
Correction of the disease phenotype in the mouse model of Stargardt disease by lentiviral gene therapy
J Kong, S-R Kim, K Binley, I Pata, K Doi, J Mannik, J Zernant-Rajang, O Kan, S Iqball, S Naylor, J R Sparrow, P Gouras and R Allikmets
Gene Ther advance online publication, May 8, 2008; doi:10.1038/gt.2008.78
Tumor cells expressing a fusion protein of MULT1 and Fas are rejected in vivo by apoptosis and NK cell activation
H S R Kotturi, J Li, M Branham-O'Connor, S L Stickel, X Yu, T E Wagner and Y Wei
Gene Ther advance online publication, May 8, 2008; doi:10.1038/gt.2008.77
Generation of lentivirus vectors using recombinant baculoviruses
H P Lesch, S Turpeinen, E A Niskanen, A J Mähönen, K J Airenne and S Ylä-Herttuala
Gene Ther advance online publication, May 8, 2008; doi:10.1038/gt.2008.76
May 1 2008
Original Articles
Oxidative stress-inducible lentiviral vectors for gene therapy
H Hurttila, J K Koponen, E Kansanen, H-K Jyrkkänen, A Kivelä, R Kylätie, S Ylä-Herttuala and A-L Levonen
Gene Ther advance online publication, May 1, 2008; doi:10.1038/gt.2008.75
Efficient entry inhibition of human and nonhuman primate immunodeficiency virus by cell surface-expressed gp41-derived peptides
R C Zahn, F G Hermann, E-Y Kim, M D Rett, S M Wolinsky, R P Johnson, F Villinger, D von Laer and J E Schmitz
Gene Ther advance online publication, May 1, 2008; doi:10.1038/gt.2008.73
April 24 2008
Review
AAV-mediated gene transfer for the treatment of hemophilia B: problems and prospects
N C Hasbrouck and K A High
Gene Ther advance online publication, April 24, 2008; doi:10.1038/gt.2008.71
Original Articles
Lentiviral transduction of the murine lung provides efficient pseudotype and developmental stage-dependent cell-specific transgene expression
S M K Buckley, S J Howe, V Sheard, N J Ward, C Coutelle, A J Thrasher, S N Waddington and T R McKay
Gene Ther advance online publication, April 24, 2008; doi:10.1038/gt.2008.74
Ex vivo adenoviral transfer of bone morphogenetic protein 12 (BMP-12) cDNA improves Achilles tendon healing in a rat model
M Majewski, O Betz, P E Ochsner, F Liu, R M Porter and C H Evans
Gene Ther advance online publication, April 24, 2008; doi:10.1038/gt.2008.48
A canine minidystrophin is functional and therapeutic in mdx mice
B Wang, J Li, C Qiao, C Chen, P Hu, X Zhu, L Zhou, J Bogan, J Kornegay and X Xiao
Gene Ther advance online publication, April 24, 2008; doi:10.1038/gt.2008.70
April 17 2008
Reviews
AAV-mediated gene therapy for retinal disorders: from mouse to man
P K Buch, J W Bainbridge and R R Ali
Gene Ther advance online publication, April 17, 2008; doi:10.1038/gt.2008.66
AAV vectors for RNA-based modulation of gene expression
O Danos
Gene Ther advance online publication, April 17, 2008; doi:10.1038/gt.2008.69
Gene therapy progress and prospects cancer: oncolytic viruses
T-C Liu and D Kirn
Gene Ther advance online publication, April 17, 2008; doi:10.1038/gt.2008.72
Clinical gene therapy using recombinant adeno-associated virus vectors
C Mueller and T R Flotte
Gene Ther advance online publication, April 17, 2008; doi:10.1038/gt.2008.68
Manufacturing and characterizing AAV-based vectors for use in clinical studies
J F Wright
Gene Ther advance online publication, April 17, 2008; doi:10.1038/gt.2008.65
Original Articles
Oral IL-10 gene delivery in a microsphere-based formulation for local transfection and therapeutic efficacy in inflammatory bowel disease
M D Bhavsar and M M Amiji
Gene Ther advance online publication, April 17, 2008; doi:10.1038/gt.2008.67
In vivo transfer of plasmid from food-grade transiting lactococci to murine epithelial cells
J-M Chatel, L Pothelune, S Ah-Leung, G Corthier, J-M Wal and P Langella
Gene Ther advance online publication, April 17, 2008; doi:10.1038/gt.2008.59
A novel magnetic approach to enhance the efficacy of cell-based gene therapies
M Muthana, S D Scott, N Farrow, F Morrow, C Murdoch, S Grubb, N Brown, J Dobson and C E Lewis
Gene Ther advance online publication, April 17, 2008; doi:10.1038/gt.2008.57
April 10 2008
Reviews
Potential of AAV vectors in the treatment of metabolic disease
I E Alexander, S C Cunningham, G J Logan and J Christodoulou
Gene Ther advance online publication, April 10, 2008; doi:10.1038/gt.2008.64
Toward exascale production of recombinant adeno-associated virus for gene transfer applications
S Cecchini, A Negrete and R M Kotin
Gene Ther advance online publication, April 10, 2008; doi:10.1038/gt.2008.61
Adeno-associated virus integration: virus versus vector
R H Smith
Gene Ther advance online publication, April 10, 2008; doi:10.1038/gt.2008.55
Original Articles
Inflammatory tumour cell killing by oncolytic reovirus for the treatment of melanoma
F Errington, C L White, K R Twigger, A Rose, K Scott, L Steele, L J Ilett, R Prestwich, H S Pandha, M Coffey, P Selby, R Vile, K J Harrington and A A Melcher
Gene Ther advance online publication, April 10, 2008; doi:10.1038/gt.2008.58
Cluster intradermal DNA vaccination rapidly induces E7-specific CD8+ T-cell immune responses leading to therapeutic antitumor effects
S Peng, C Trimble, R D Alvarez, W K Huh, Z Lin, A Monie, C-F Hung and T-C Wu
Gene Ther advance online publication, April 10, 2008; doi:10.1038/gt.2008.53
Changing the adenovirus fiber for retaining gene delivery efficacy in the presence of neutralizing antibodies
M Särkioja, S Pesonen, M Raki, T Hakkarainen, J Salo, M T Ahonen, A Kanerva and A Hemminki
Gene Ther advance online publication, April 10, 2008; doi:10.1038/gt.2008.56
The size of endothelial fenestrae in human liver sinusoids: implications for hepatocyte-directed gene transfer
E Wisse, F Jacobs, B Topal, P Frederik and B De Geest
Gene Ther advance online publication, April 10, 2008; doi:10.1038/gt.2008.60
April 3 2008
Review
Immunity to adeno-associated virus vectors in animals and humans: a continued challenge
A K Zaiss and D A Muruve
Gene Ther advance online publication, April 3, 2008; doi:10.1038/gt.2008.54
Original Articles
Tissue-specific restriction of cyclophilin A-independent HIV-1- and SIV-derived lentiviral vectors
C A Kahl, P M Cannon, J Oldenburg, A F Tarantal and D B Kohn
Gene Ther advance online publication, April 3, 2008; doi:10.1038/gt.2008.50
Ultrasound with microbubbles enhances gene expression of plasmid DNA in the liver via intraportal delivery
Z P Shen, A A Brayman, L Chen and C H Miao
Gene Ther advance online publication, April 3, 2008; doi:10.1038/gt.2008.51
March 27 2008
Original Articles
Efficient gene transfer in skeletal muscle with AAV-derived bicistronic vector using the FGF-1 IRES
A Delluc-Clavières, C Le Bec, L Van den Berghe, C Conte, V Allo, O Danos and A-C Prats
Gene Ther advance online publication, March 27, 2008; doi:10.1038/gt.2008.49
Baculovirus-mediated interferon alleviates dimethylnitrosamine-induced liver cirrhosis symptoms in a murine model
Y Nishibe, H Kaneko, H Suzuki, T Abe, Y Matsuura and H Takaku
Gene Ther advance online publication, March 27, 2008; doi:10.1038/gt.2008.29
Absence of retroviral vector-mediated transformation of gene-modified T cells after long-term engraftment in mice
J A Westwood, W K Murray, M Trivett, A Shin, P Neeson, D P MacGregor, N M Haynes, J A Trapani, P Mayura-Guru, S Fox, S Peinert, D Honemann, H M Prince, D Ritchie, A M Scott, F E Smyth, M J Smyth, P K Darcy and M H Kershaw
Gene Ther advance online publication, March 27, 2008; doi:10.1038/gt.2008.47
Short Communication
Potential genotoxicity from integration sites in CLAD dogs treated successfully with gammaretroviral vector-mediated gene therapy
M Hai, R L Adler, T R Bauer Jr, L M Tuschong, Y-C Gu, X Wu and D D Hickstein
Gene Ther advance online publication, March 27, 2008; doi:10.1038/gt.2008.52
March 20 2008
Original Articles
Connective tissue growth factor linked to the E7 tumor antigen generates potent antitumor immune responses mediated by an antiapoptotic mechanism
W-F Cheng, M-C Chang, W-Z Sun, C-N Lee, H-W Lin, Y-N Su, C-Y Hsieh and C-A Chen
Gene Ther advance online publication, March 20, 2008; doi:10.1038/gt.2008.25
Heat shock protein inhibitors increase the efficacy of measles virotherapy
C Liu, C Erlichman, C J McDonald, J N Ingle, P Zollman, I Iankov, S J Russell and E Galanis
Gene Ther advance online publication, March 20, 2008; doi:10.1038/gt.2008.30
Repopulation of B-lymphocytes with restricted gene expression using haematopoietic stem cells engineered with lentiviral vectors
T E Taher, C Tulone, R Fatah, F D'Acquisto, D J Gould and R A Mageed
Gene Ther advance online publication, March 20, 2008; doi:10.1038/gt.2008.33
March 13 2008
Original Articles
Site-specific gene modification by oligodeoxynucleotides in mouse bone marrow-derived mesenchymal stem cells
K Flagler, V Alexeev, E A Pierce and O Igoucheva
Gene Ther advance online publication, March 13, 2008; doi:10.1038/gt.2008.31
Targeting gene expression to cones with human cone opsin promoters in recombinant AAV
A M Komáromy, J J Alexander, A E Cooper, V A Chiodo, G M Acland, W W Hauswirth and G D Aguirre
Gene Ther advance online publication, March 13, 2008; doi:10.1038/gt.2008.32
RNA-loaded CD40-activated B cells stimulate antigen-specific T-cell responses in dogs with spontaneous lymphoma
N J Mason, C M Coughlin, B Overley, J N Cohen, E L Mitchell, T A Colligon, C A Clifford, A Zurbriggen, K U Sorenmo and R H Vonderheide
Gene Ther advance online publication, March 13, 2008; doi:10.1038/gt.2008.22
March 6 2008
Original Articles
Improved lentiviral vectors for Wiskott–Aldrich syndrome gene therapy mimic endogenous expression profiles throughout haematopoiesis
C Frecha, M G Toscano, C Costa, M J Saez-Lara, F L Cosset, E Verhoeyen and F Martin
Gene Ther advance online publication, March 6, 2008; doi:10.1038/gt.2008.20
AAV–BDNF mediated attenuation of quinolinic acid-induced neuropathology and motor function impairment
A P Kells, R A Henry and B Connor
Gene Ther advance online publication, March 6, 2008; doi:10.1038/gt.2008.23
Development of an enhanced B-specific lentiviral vector expressing BTK: a tool for gene therapy of XLA
T Moreau, V Barlogis, F Bardin, J A Nunes, B Calmels, C Chabannon and C Tonnelle
Gene Ther advance online publication, March 6, 2008; doi:10.1038/gt.2008.17
Characterization of the adaptive and innate immune response to intravenous oncolytic reovirus (Dearing type 3) during a phase I clinical trial
C L White, K R Twigger, L Vidal, J S De Bono, M Coffey, L Heinemann, R Morgan, A Merrick, F Errington, R G Vile, A A Melcher, H S Pandha and K J Harrington
Gene Ther advance online publication, March 6, 2008; doi:10.1038/gt.2008.21
Adenovirus targeting to HLA-A1/MAGE-A1-positive tumor cells by fusing a single-chain T-cell receptor with minor capsid protein IX
J de Vrij, T G Uil, S K van den Hengel, S J Cramer, D Koppers-Lalic, M C Verweij, E J H J Wiertz, J Vellinga, R A Willemsen and R C Hoeben
Gene Ther advance online publication, March 6, 2008; doi:10.1038/gt.2008.26
Short Communication
Atelocollagen-mediated local and systemic applications of myostatin-targeting siRNA increase skeletal muscle mass
N Kinouchi, Y Ohsawa, N Ishimaru, H Ohuchi, Y Sunada, Y Hayashi, Y Tanimoto, K Moriyama and S Noji
Gene Ther advance online publication, March 6, 2008; doi:10.1038/gt.2008.24
February 21 2008
Original Article
Wild-type adenoviruses from groups A–F evoke unique innate immune responses, of which HAd3 and SAd23 are partially complement dependent
D M Appledorn, A Kiang, A McBride, H Jiang, S Seregin, J M Scott, R Stringer, Y Kousa, M Hoban, M M Frank and A Amalfitano
Gene Ther advance online publication, February 21, 2008; doi:10.1038/gt.2008.18