ADVANCE ONLINE PUBLICATION

The latest research papers, published online ahead of print. These online versions are definitive and may be cited using the digital object identifier (DOI).
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July 9 2009

Review

Engineering ligand-responsive gene-control elements: lessons learned from natural riboswitches

K H Link and R R Breaker

Gene Ther advance online publication, July 9, 2009; doi:10.1038/gt.2009.81

Original Articles

Mannitol-facilitated CNS entry of rAAV2 vector significantly delayed the neurological disease progression in MPS IIIB mice

D M McCarty, J DiRosario, K Gulaid, J Muenzer and H Fu

Gene Ther advance online publication, July 9, 2009; doi:10.1038/gt.2009.85

Lister strain of vaccinia virus armed with endostatin–angiostatin fusion gene as a novel therapeutic agent for human pancreatic cancer

J R Tysome, A Briat, G Alusi, F Cao, D Gao, J Yu, P Wang, S Yang, Z Dong, S Wang, L Deng, J Francis, T Timiryasova, I Fodor, N R Lemoine and Y Wang

Gene Ther advance online publication, July 9, 2009; doi:10.1038/gt.2009.74

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July 2 2009

Original Articles

Ultrasound-targeted microbubble destruction enhances AAV-mediated gene transfection in human RPE cells in vitro and rat retina in vivo

H L Li, X Z Zheng, H P Wang, F Li, Y Wu and L F Du

Gene Ther advance online publication, July 2, 2009; doi:10.1038/gt.2009.84

Immunological priming potentiates non-viral anti-inflammatory gene therapy treatment of neuropathic pain

E Sloane, S Langer, B Jekich, J Mahoney, T Hughes, M Frank, W Seibert, G Huberty, B Coats, J Harrison, D Klinman, S Poole, S Maier, K Johnson, R Chavez, L R Watkins, L Leinwand and E Milligan

Gene Ther advance online publication, July 2, 2009; doi:10.1038/gt.2009.79

Fragile X mental retardation protein replacement restores hippocampal synaptic function in a mouse model of fragile X syndrome

Z Zeier, A Kumar, K Bodhinathan, J A Feller, T C Foster and D C Bloom

Gene Ther advance online publication, July 2, 2009; doi:10.1038/gt.2009.83

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June 25 2009

News and Commentary

Translational stability for sickle gene therapy FREE

M C Walters

Gene Ther advance online publication, June 25, 2009; doi:10.1038/gt.2009.70

Original Articles

Redirecting human CD4+CD25+ regulatory T cells from the peripheral blood with pre-defined target specificity

A A Hombach, D Kofler, G Rappl and H Abken

Gene Ther advance online publication, June 25, 2009; doi:10.1038/gt.2009.75

An immobilized nanoparticle-based platform for efficient gene knockdown of targeted cells in the circulation

Z Huang and M R King

Gene Ther advance online publication, June 25, 2009; doi:10.1038/gt.2009.76

Human neural stem cells overexpressing glial cell line-derived neurotrophic factor in experimental cerebral hemorrhage

H J Lee, I H Park, H J Kim and S U Kim

Gene Ther advance online publication, June 25, 2009; doi:10.1038/gt.2009.51

CR1/2 is an important suppressor of Adenovirus-induced innate immune responses and is required for induction of neutralizing antibodies

S S Seregin, Y A Aldhamen, D M Appledorn, N J Schuldt, A J McBride, M Bujold, S S Godbehere and A Amalfitano

Gene Ther advance online publication, June 25, 2009; doi:10.1038/gt.2009.77

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June 11 2009

Short Communications

Non-cell-autonomous effects of vector-expressed regulatory RNAs in mammalian heart cells

E Kizana, E Cingolani and E Marbán

Gene Ther advance online publication, June 11, 2009; doi:10.1038/gt.2009.64

Development of fiber-substituted adenovirus vectors containing foreign peptides in the adenovirus serotype 35 fiber knob

H Matsui, F Sakurai, S Kurachi, K Tashiro, K Sugio, K Kawabata, K Yamanishi and H Mizuguchi

Gene Ther advance online publication, June 11, 2009; doi:10.1038/gt.2009.65

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June 4 2009

Original Article

Double E1B 19 kDa- and E1B 55 kDa-deleted oncolytic adenovirus in combination with radiotherapy elicits an enhanced anti-tumor effect

J Kim, P-H Kim, J Y Yoo, A-R Yoon, H J Choi, J Seong, I-W Kim, J-H Kim and C-O Yun

Gene Ther advance online publication, June 4, 2009; doi:10.1038/gt.2009.72

Short Communication

Efficient nonviral Sleeping Beauty transposon-based TCR gene transfer to peripheral blood lymphocytes confers antigen-specific antitumor reactivity

P D Peng, C J Cohen, S Yang, C Hsu, S Jones, Y Zhao, Z Zheng, S A Rosenberg and R A Morgan

Gene Ther advance online publication, June 4, 2009; doi:10.1038/gt.2009.54

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May 28 2009

Original Articles

siRNA silencing of keratinocyte-specific GFP expression in a transgenic mouse skin model

E Gonzalez-Gonzalez, H Ra, R P Hickerson, Q Wang, W Piyawattanametha, M J Mandella, G S Kino, D Leake, A A Avilion, O Solgaard, T C Doyle, C H Contag and R L Kaspar

Gene Ther advance online publication, May 28, 2009; doi:10.1038/gt.2009.62

Analysis of neuronal proliferation, migration and differentiation in the postnatal brain using equine infectious anemia virus-based lentiviral vectors

B V Jacquet, M Patel, M Iyengar, H Liang, B Therit, R Salinas-Mondragon, C Lai, J C Olsen, E S Anton and H T Ghashghaei

Gene Ther advance online publication, May 28, 2009; doi:10.1038/gt.2009.58

Systemic delivery of AAV8 in utero results in gene expression in diaphragm and limb muscle: treatment implications for muscle disorders

B M Koppanati, J Li, X Xiao and P R Clemens

Gene Ther advance online publication, May 28, 2009; doi:10.1038/gt.2009.71

PML has a predictive role in tumor cell permissiveness to interferon-sensitive oncolytic viruses

P T Sobol, J L Hummel, R M Rodrigues and K L Mossman

Gene Ther advance online publication, May 28, 2009; doi:10.1038/gt.2009.68

Therapeutic silencing of an endogenous gene by siRNA cream in an arthritis model mouse

M Takanashi, K Oikawa, K Sudo, M Tanaka, K Fujita, A Ishikawa, S Nakae, R L Kaspar, M Matsuzaki, M Kudo and M Kuroda

Gene Ther advance online publication, May 28, 2009; doi:10.1038/gt.2009.66

A muscle-targeting peptide displayed on AAV2 improves muscle tropism on systemic delivery

C-Y Yu, Z Yuan, Z Cao, B Wang, C Qiao, J Li and X Xiao

Gene Ther advance online publication, May 28, 2009; doi:10.1038/gt.2009.59

Short Communication

Adenovirus-mediated gene transfer of fibromodulin inhibits neointimal hyperplasia in an organ culture model of human saphenous vein graft disease

P Ranjzad, H K Salem and P A Kingston

Gene Ther advance online publication, May 28, 2009; doi:10.1038/gt.2009.63

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May 21 2009

Original Article

Gene transfer using bovine adeno-associated virus in the guinea pig cochlea

S B Shibata, G Di Pasquale, S R Cortez, J A Chiorini and Y Raphael

Gene Ther advance online publication, May 21, 2009; doi:10.1038/gt.2009.57

Short Communication

In vitro analysis of cidofovir and genetically engineered TK expression as potential approaches for the intervention of ColoAd1-based treatment of cancer

M Bauzon, F Jin, P Kretschmer and T Hermiston

Gene Ther advance online publication, May 21, 2009; doi:10.1038/gt.2009.69

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May 14 2009

Original Articles

Ad5/3-9HIF-Delta24-VEGFR-1-Ig, an infectivity enhanced, dual-targeted and antiangiogenic oncolytic adenovirus for kidney cancer treatment

K Guse, I Diaconu, M Rajecki, M Sloniecka, T Hakkarainen, A Ristimäki, A Kanerva, S Pesonen and A Hemminki

Gene Ther advance online publication, May 14, 2009; doi:10.1038/gt.2009.56

Chitosan–plasmid nanoparticle formulations for IM and SC delivery of recombinant FGF-2 and PDGF-BB or generation of antibodies

M Jean, F Smaoui, M Lavertu, S Méthot, L Bouhdoud, M D Buschmann and A Merzouki

Gene Ther advance online publication, May 14, 2009; doi:10.1038/gt.2009.60

Shortened ALK1 regulatory fragment maintains a specific activity in arteries feeding ischemic tissues

X Li, Y Yonenaga and T Seki

Gene Ther advance online publication, May 14, 2009; doi:10.1038/gt.2009.53

Lentiviral vectors with amplified beta cell-specific gene expression

K L Shaw, E Pais, S Ge, C Hardee, D Skelton, R P Hollis, G M Crooks and D B Kohn

Gene Ther advance online publication, May 14, 2009; doi:10.1038/gt.2009.49

Transgene-specific host responses in cutaneous gene therapy: the role of cells expressing the transgene

Z Zhang, C Kuscu and S Ghazizadeh

Gene Ther advance online publication, May 14, 2009; doi:10.1038/gt.2009.67

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May 7 2009

Original Article

Subconjunctival gene delivery of the transcription factor GA-binding protein delays corneal neovascularization in a mouse model

K C Yoon, J A Bae, H J Park, S K Im, H J Oh, X H Lin, M Y Kim, J H Lee, S E Lee, K Y Ahn and K K Kim

Gene Ther advance online publication, May 7, 2009; doi:10.1038/gt.2009.50

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