ADVANCE ONLINE PUBLICATION
The latest research papers, published online ahead of print. These online versions are definitive and may be cited using the digital object identifier (DOI).
About advance online publication
July 10 2008 |
July 3 2008 |
June 26 2008 |
June 19 2008 |
June 12 2008 |
June 5 2008 |
May 29 2008 |
May 22 2008 |
May 15 2008 |
May 8 2008 |
May 1 2008 |
April 24 2008 |
April 17 2008 |
April 10 2008 |
April 3 2008
July 17 2008
Original Articles
Persistent episomal transgene expression in liver following delivery of a scaffold/matrix attachment region containing non-viral vector
O Argyros, S P Wong, M Niceta, S N Waddington, S J Howe, C Coutelle, A D Miller and R P Harbottle
Gene Ther advance online publication, July 17, 2008; doi:10.1038/gt.2008.113
Ex vivo-transduced autologous skin fibroblasts expressing human Lim mineralization protein-3 efficiently form new bone in animal models
W Lattanzi, C Parrilla, A Fetoni, G Logroscino, G Straface, G Pecorini, E Stigliano, A Tampieri, R Bedini, R Pecci, F Michetti, A Gambotto, P D Robbins and E Pola
Gene Ther advance online publication, July 17, 2008; doi:10.1038/gt.2008.116
Novel anti-VEGF chimeric molecules delivered by AAV vectors for inhibition of retinal neovascularization
P Pechan, H Rubin, M Lukason, J Ardinger, E DuFresne, W W Hauswirth, S C Wadsworth and A Scaria
Gene Ther advance online publication, July 17, 2008; doi:10.1038/gt.2008.115
Treatment of avascular necrosis of the femoral head by hepatocyte growth factor-transgenic bone marrow stromal stem cells
Q Wen, L Ma, Y-P Chen, L Yang, W Luo and X-N Wang
Gene Ther advance online publication, July 17, 2008; doi:10.1038/gt.2008.110
July 10 2008
Original Articles
Complex interactions with several arms of the complement system dictate innate and humoral immunity to adenoviral vectors
D M Appledorn, A McBride, S Seregin, J M Scott, N Schuldt, A Kiang, S Godbehere and A Amalfitano
Gene Ther advance online publication, July 10, 2008; doi:10.1038/gt.2008.114
Augmentation of AAV-mediated cardiac gene transfer after systemic administration in adult rats
O J Müller, S Schinkel, J A Kleinschmidt, H A Katus and R Bekeredjian
Gene Ther advance online publication, July 10, 2008; doi:10.1038/gt.2008.111
July 3 2008
Original Article
Cancer gene therapy using mesenchymal stem cells expressing interferon-
in a mouse prostate cancer lung metastasis model
C Ren, S Kumar, D Chanda, L Kallman, J Chen, J D Mountz and S Ponnazhagan
Gene Ther advance online publication, July 3, 2008; doi:10.1038/gt.2008.101
June 26 2008
Original Article
Lentiviral-vector-mediated expression of murine IL-1 receptor antagonist or IL-10 reduces the severity of endotoxin-induced uveitis
P Trittibach, S E Barker, C A Broderick, M Natkunarajah, Y Duran, S J Robbie, J W B Bainbridge, A J Smith, G-M Sarra, A D Dick and R R Ali
Gene Ther advance online publication, June 26, 2008; doi:10.1038/gt.2008.109
Short Communications
Automated analysis of viral integration sites in gene therapy research using the SeqMap web resource
B Peters, S Dirscherl, J Dantzer, J Nowacki, S Cross, X Li, K Cornetta, M C Dinauer and S D Mooney
Gene Ther advance online publication, June 26, 2008; doi:10.1038/gt.2008.99
Autophagy-inducing agents augment the antitumor effect of telerase-selve oncolytic adenovirus OBP-405 on glioblastoma cells
T Yokoyama, E Iwado, Y Kondo, H Aoki, Y Hayashi, M M Georgescu, R Sawaya, K R Hess, G B Mills, H Kawamura, Y Hashimoto, Y Urata, T Fujiwara and S Kondo
Gene Ther advance online publication, June 26, 2008; doi:10.1038/gt.2008.98
June 19 2008
Original Articles
Quantitative analysis of clinically relevant mutations occurring in lymphoid cells harboring 
-retrovirus-encoded hsvtk suicide genes
X Wang, M Olszewska, V Capacio, J Stefanski, M Przybylowski, S Samakoglu, A H Chang, M Sadelain and I Rivière
Gene Ther advance online publication, June 19, 2008; doi:10.1038/gt.2008.103
Construction and analysis of compact muscle-specific promoters for AAV vectors
B Wang, J Li, F H Fu, C Chen, X Zhu, L Zhou, X Jiang and X Xiao
Gene Ther advance online publication, June 19, 2008; doi:10.1038/gt.2008.104
Short Communications
Local delivery of VEGF adenovirus to the uterine artery increases vasorelaxation and uterine blood flow in the pregnant sheep
A L David, B Torondel, I Zachary, V Wigley, K A Nader, V Mehta, S M K Buckley, T Cook, M Boyd, C H Rodeck, J Martin and D M Peebles
Gene Ther advance online publication, June 19, 2008; doi:10.1038/gt.2008.102
NOD/SCID repopulating cells contribute only to short-term repopulation in the baboon
P Mezquita, B C Beard and H-P Kiem
Gene Ther advance online publication, June 19, 2008; doi:10.1038/gt.2008.108
June 12 2008
Original Article
Canstatin gene electrotransfer combined with radiotherapy: preclinical trials for cancer treatment
C Magnon, P Opolon, E Connault, L M Mir, M Perricaudet and D Martel-Renoir
Gene Ther advance online publication, June 12, 2008; doi:10.1038/gt.2008.100
June 5 2008
Review
Gene therapy progress and prospects: synthetic polymer-based systems
D Schaffert and E Wagner
Gene Ther advance online publication, June 5, 2008; doi:10.1038/gt.2008.105
Original Article
Drug-inducible and simultaneous regulation of endogenous genes by single-chain nuclear receptor-based zinc-finger transcription factor gene switches
L Magnenat, L J Schwimmer and C F Barbas III
Gene Ther advance online publication, June 5, 2008; doi:10.1038/gt.2008.96
May 29 2008
Original Articles
Targeted inhibition of platelet-derived growth factor receptor- subunit in hepatic stellate cells ameliorates hepatic fibrosis in rats
S-W Chen, Y-X Chen, X-R Zhang, H Qian, W-Z Chen and W-F Xie
Gene Ther advance online publication, May 29, 2008; doi:10.1038/gt.2008.93
Cell entry targeting restricts biodistribution of replication-competent retroviruses to tumour tissue
L J Duerner, A Schwantes, I C Schneider, K Cichutek and C J Buchholz
Gene Ther advance online publication, May 29, 2008; doi:10.1038/gt.2008.92
Short Communication
Syncytia formation affects the yield and cytotoxicity of an adenovirus expressing a fusogenic glycoprotein at a late stage of replication
S Guedan, A Gros, M Cascallo, R Vile, E Mercade and R Alemany
Gene Ther advance online publication, May 29, 2008; doi:10.1038/gt.2008.94
May 22 2008
Original Articles
Site-specific, Rep-mediated integration of the intact -globin locus in the human erythroleukaemic cell line K562
S E Howden, L Voullaire, H Wardan, R Williamson and J Vadolas
Gene Ther advance online publication, May 22, 2008; doi:10.1038/gt.2008.84
ICP10PK inhibits calpain-dependent release of apoptosis-inducing factor and programmed cell death in response to the toxin MPP+
S Q Wales, J M Laing, L Chen and L Aurelian
Gene Ther advance online publication, May 22, 2008; doi:10.1038/gt.2008.88
Development of optimal bicistronic lentiviral vectors facilitates high-level TCR gene expression and robust tumor cell recognition
S Yang, C J Cohen, P D Peng, Y Zhao, L Cassard, Z Yu, Z Zheng, S Jones, N P Restifo, S A Rosenberg and R A Morgan
Gene Ther advance online publication, May 22, 2008; doi:10.1038/gt.2008.90
Short Communication
Strategies for improving the transduction efficiency of single-stranded adeno-associated virus vectors in vitro and in vivo
G R Jayandharan, L Zhong, B Li, B Kachniarz and A Srivastava
Gene Ther advance online publication, May 22, 2008; doi:10.1038/gt.2008.89
May 15 2008
Original Articles
Targeted delivery of a suicide gene to human colorectal tumors by a conditionally replicating vaccinia virus
J Foloppe, J Kintz, N Futin, A Findeli, P Cordier, Y Schlesinger, C Hoffmann, C Tosch, J-M Balloul and P Erbs
Gene Ther advance online publication, May 15, 2008; doi:10.1038/gt.2008.82
Visualization of targeted transduction by engineered lentiviral vectors
K-I Joo and P Wang
Gene Ther advance online publication, May 15, 2008; doi:10.1038/gt.2008.87
Immunogenicity and safety profiles of genetic vaccines against human Her-2/neu in cynomolgus monkeys
H-J Ko, Y-J Kim, Y-S Kim, J-M Kim, S-H Ho, J-G Jeong, S-M Oh, J-A Chae, C-Y Kim, P-S Lee and C-Y Kang
Gene Ther advance online publication, May 15, 2008; doi:10.1038/gt.2008.81
Engineering of highly immunogenic long-lived DC vaccines by antiapoptotic protein gene transfer to enhance cancer vaccine potency
T Yoshikawa, T Niwa, H Mizuguchi, N Okada and S Nakagawa
Gene Ther advance online publication, May 15, 2008; doi:10.1038/gt.2008.85
May 8 2008
Original Articles
Enhancement of CD4+ T-cell help reverses the doxorubicin-induced suppression of antigen-specific immune responses in vaccinated mice
D Kim, A Monie, Y-C Tsai, L He, M-C Wang, C-F Hung and T-C Wu
Gene Ther advance online publication, May 8, 2008; doi:10.1038/gt.2008.79
Correction of the disease phenotype in the mouse model of Stargardt disease by lentiviral gene therapy
J Kong, S-R Kim, K Binley, I Pata, K Doi, J Mannik, J Zernant-Rajang, O Kan, S Iqball, S Naylor, J R Sparrow, P Gouras and R Allikmets
Gene Ther advance online publication, May 8, 2008; doi:10.1038/gt.2008.78
Tumor cells expressing a fusion protein of MULT1 and Fas are rejected in vivo by apoptosis and NK cell activation
H S R Kotturi, J Li, M Branham-O'Connor, S L Stickel, X Yu, T E Wagner and Y Wei
Gene Ther advance online publication, May 8, 2008; doi:10.1038/gt.2008.77
Generation of lentivirus vectors using recombinant baculoviruses
H P Lesch, S Turpeinen, E A Niskanen, A J Mähönen, K J Airenne and S Ylä-Herttuala
Gene Ther advance online publication, May 8, 2008; doi:10.1038/gt.2008.76
May 1 2008
Original Articles
Oxidative stress-inducible lentiviral vectors for gene therapy
H Hurttila, J K Koponen, E Kansanen, H-K Jyrkkänen, A Kivelä, R Kylätie, S Ylä-Herttuala and A-L Levonen
Gene Ther advance online publication, May 1, 2008; doi:10.1038/gt.2008.75
Efficient entry inhibition of human and nonhuman primate immunodeficiency virus by cell surface-expressed gp41-derived peptides
R C Zahn, F G Hermann, E-Y Kim, M D Rett, S M Wolinsky, R P Johnson, F Villinger, D von Laer and J E Schmitz
Gene Ther advance online publication, May 1, 2008; doi:10.1038/gt.2008.73
April 24 2008
Original Articles
Lentiviral transduction of the murine lung provides efficient pseudotype and developmental stage-dependent cell-specific transgene expression
S M K Buckley, S J Howe, V Sheard, N J Ward, C Coutelle, A J Thrasher, S N Waddington and T R McKay
Gene Ther advance online publication, April 24, 2008; doi:10.1038/gt.2008.74
Ex vivo adenoviral transfer of bone morphogenetic protein 12 (BMP-12) cDNA improves Achilles tendon healing in a rat model
M Majewski, O Betz, P E Ochsner, F Liu, R M Porter and C H Evans
Gene Ther advance online publication, April 24, 2008; doi:10.1038/gt.2008.48
April 17 2008
Original Articles
Oral IL-10 gene delivery in a microsphere-based formulation for local transfection and therapeutic efficacy in inflammatory bowel disease
M D Bhavsar and M M Amiji
Gene Ther advance online publication, April 17, 2008; doi:10.1038/gt.2008.67
In vivo transfer of plasmid from food-grade transiting lactococci to murine epithelial cells
J-M Chatel, L Pothelune, S Ah-Leung, G Corthier, J-M Wal and P Langella
Gene Ther advance online publication, April 17, 2008; doi:10.1038/gt.2008.59
April 10 2008
Original Articles
Inflammatory tumour cell killing by oncolytic reovirus for the treatment of melanoma
F Errington, C L White, K R Twigger, A Rose, K Scott, L Steele, L J Ilett, R Prestwich, H S Pandha, M Coffey, P Selby, R Vile, K J Harrington and A A Melcher
Gene Ther advance online publication, April 10, 2008; doi:10.1038/gt.2008.58
Cluster intradermal DNA vaccination rapidly induces E7-specific CD8+ T-cell immune responses leading to therapeutic antitumor effects
S Peng, C Trimble, R D Alvarez, W K Huh, Z Lin, A Monie, C-F Hung and T-C Wu
Gene Ther advance online publication, April 10, 2008; doi:10.1038/gt.2008.53
The size of endothelial fenestrae in human liver sinusoids: implications for hepatocyte-directed gene transfer
E Wisse, F Jacobs, B Topal, P Frederik and B De Geest
Gene Ther advance online publication, April 10, 2008; doi:10.1038/gt.2008.60