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June 1999, Volume 6, Number 6

Table of Contents

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Editorial
Molecular switches for regulating therapeutic genes FREE
K A Webster
Abstract  |  Full text  |  PDF 951
Perspective
Coronary angioplasty: an end to early closing? FREE
W J Gullick & C Lewanski
Abstract  |  Full text  |  PDF 954
Papers
Targeting endogenous platelet-derived growth factor B-chain by adenovirus-mediated gene transfer potently inhibits in vivo smooth muscle proliferation after arterial injury FREE
J Deguchi, T Namba, H Hamada, T Nakaoka, J Abe, O Sato, T Miyata, M Makuuchi, K Kurokawa & Y Takuwa
Abstract  |  Full text  |  PDF 956
Improved gene transfer into canine hematopoietic repopulating cells using CD34-enriched marrow cells in combination with a gibbon ape leukemia virus-pseudotype retroviral vector FREE
H-P Kiem, P A McSweeney, B Bruno, M Goerner, G Buron, J Morris, R Storb & A D Miller
Abstract  |  Full text  |  PDF 966
Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield FREE
S Zolotukhin, B J Byrne, E Mason, I Zolotukhin, M Potter, K Chesnut, C Summerford, R J Samulski & N Muzyczka
Abstract  |  Full text  |  PDF 973
High-titer recombinant adeno-associated virus production utilizing a recombinant herpes simplex virus type I vector expressing AAV-2 Rep and Cap FREE
J E Conway, CMJ ap Rhys, I Zolotukhin, S Zolotukhin, N Muzyczka, G S Hayward & B J Byrne
Abstract  |  Full text  |  PDF 986
Liposome-mediated NGF gene transfection following neuronal injury: potential therapeutic applications FREE
L L Zou, L Huang, R L Hayes, C Black, Y H Qiu, J R Perez-Polo, W Le, G L Clifton & K Yang
Abstract  |  Full text  |  PDF 994
Cell-specific nuclear import of plasmid DNA FREE
J Vacik, B S Dean, W E Zimmer & D A Dean
Abstract  |  Full text  |  PDF 1006
IGF-I gene transfer in thermally injured rats FREE
M G Jeschke, R E Barrow, H K Hawkins, K Yang, R L Hayes, B J Lichtenbelt, J R Perez-Polo & D N Herndon
Abstract  |  Full text  |  PDF 1015
Differential expression and secretion of alpha 1 anti-trypsin between direct DNA injection and implantation of transfected myoblast FREE
G Bou-Gharios, D J Wells, Q L Lu, J E Morgan & T Partridge
Abstract  |  Full text  |  PDF 1021
Therapeutic efficacy of the thymidine kinase/ganciclovir system on large experimental gliomas: a nuclear magnetic resonance imaging study FREE
R Bouali-Benazzouz, M Lainé, J M Vicat, S Boisseau, C Rémy, N Fouilhé, F Thomas, M F Nissou, A L Benabid & F Berger
Abstract  |  Full text  |  PDF 1030
Development of a modified selective amplifier gene for hematopoietic stem cell gene therapy FREE
K M Matsuda, A Kume, Y Ueda, M Urabe, M Hasegawa & K Ozawa
Abstract  |  Full text  |  PDF 1038
Cellular contaminants of adeno-associated virus vector stocks can enhance transduction FREE
L Tenenbaum, M Hamdane, M Pouzet, B Avalosse, A Stathopoulos, F Jurysta, C Rosenbaum, C O Hanemann, M Levivier & T Velu
Abstract  |  Full text  |  PDF 1045
Induction of apoptosis and G2/M arrest by infection with replication-deficient adenovirus at high multiplicity of infection FREE
K Brand, R Klocke, A Pobetaling, D Paul & M Strauss
Abstract  |  Full text  |  PDF 1054
Increase of BCNU sensitivity by wt-p53 gene therapy in glioblastoma lines depends on the administration schedule FREE
A Biroccio, D Del Bufalo, A Ricca, C D'Angelo, G D'Orazi, A Sacchi, S Soddu & G Zupi
Abstract  |  Full text  |  PDF 1064
Induction of complement attack on human cells by Gal(alpha1,3)Gal xenoantigen expression as a gene therapy approach to cancer FREE
U Jäger, Y Takeuchi & C D Porter
Abstract  |  Full text  |  PDF 1073
Retroviral transduction of quiescent haematopoietic cells using a packaging cell line expressing the membrane-bound form of stem cell factor FREE
A Sehgal, N Weeratunge & C Casimir
Abstract  |  Full text  |  PDF 1084
Overexpression of urokinase receptor in mammalian cells following administration of the in vitro transcribed encoding mRNA FREE
K Karikó, A Kuo & E S Barnathan
Abstract  |  Full text  |  PDF 1092
'Autoreplication' of the vector genome in recombinant adenoviral vectors with different E1 region deletions and transgenes FREE
U Marienfeld, A Haack, P Thalheimer, S Schneider-Rasp, H-H Brackmann & W Poller
Abstract  |  Full text  |  PDF 1101
The sCYMV1 hairpin ribozyme: targeting rules and cleavage of heterologous RNA FREE
Y Lian, M B De Young, A Siwkowski, A Hampel & J Rappaport
Abstract  |  Full text  |  PDF 1114
Augmentation of local antitumor immunity in the liver by tumor vaccine modified to secrete murine interleukin 12 FREE
N Fuji, H Fujiwara, Y Ueda, F Taniguchi, T Yoshimura, T Oka & H Yamagishi
Abstract  |  Full text  |  PDF 1120
Augmentation of natural immunity to a pro-inflammatory cytokine (TNF-alpha) by targeted DNA vaccine confers long-lasting resistance to experimental autoimmune encephalomyelitis FREE
G Wildbaum & N Karin
Abstract  |  Full text  |  PDF 1128
Ganciclovir-mediated in vivo elimination of myeloid leukemic cells expressing the HSVtk gene induces HSVtk loss variants FREE
E Braakman, R Vogels, A C M Martens, J Vermeulen, M Bron, P M Hoogerbrugge, D Valerio & A Hagenbeek
Abstract  |  Full text  |  PDF 1139
Noradrenaline transporter gene transfer for radiation cell kill by 131I meta-iodobenzylguanidine FREE
M Boyd, S H Cunningham, M M Brown, R J Mairs & T E Wheldon
Abstract  |  Full text  |  PDF 1147
A novel endothelial cell-based gene therapy platform for the in vivo delivery of apolipoprotein E FREE
L Cioffi, F G Sturtz, S Wittmer, B Barut, J Smith-Gbur, V Moore, T Zupancic, B Gilligan, R Auerbach, F Gomez, F Chauvin, M Antczak, D Platika & H R Snodgrass
Abstract  |  Full text  |  PDF 1153
Lentivirus-mediated Bcl-2 expression in bold betaTC-tet cells improves resistance to hypoxia and cytokine-induced apoptosis while preserving in vitro and in vivo control of insulin secretion FREE
P Dupraz, C Rinsch, W F Pralong, E Rolland, R Zufferey, D Trono & B Thorens
Abstract  |  Full text  |  PDF 1160
Brief communication
Retrovirus-mediated WASP gene transfer corrects defective actin polymerization in B cell lines from Wiskott-Aldrich syndrome patients carrying 'null' mutations FREE
F Candotti, F Facchetti, L Blanzuoli, D M Stewart, D L Nelson & R M Blaese
Abstract  |  Full text  |  PDF 1170
Elimination of lysosomal storage in brains of MPS VII mice treated by intrathecal administration of an adeno-associated virus vector FREE
S S Elliger, C A Elliger, C P Aguilar, N R Raju & G L Watson
Abstract  |  Full text  |  PDF 1175
Cationic lipids are essential for gene delivery mediated by intravenous administration of lipoplexes FREE
L G Barron, L S Uyechi & F C Szoka Jr
Abstract  |  Full text  |  PDF 1179
Tissue-selective expression of dominant-negative proteins for the regulation of vascular smooth muscle cell proliferation FREE
J F Schmitt, M-C Keogh, U Dennehy, D Chen, F Lupu, K Weston, D Taylor, V V Kakkar & N R Lemoine
Abstract  |  Full text  |  PDF 1184
Insulation of a conditionally expressed transgene in an adenoviral vector FREE
G Vassaux, H C Hurst & N R Lemoine
Abstract  |  Full text  |  PDF 1192
June 1999, Volume 6, Number 6
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