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April 1999, Volume 6, Number 4

Table of Contents

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Editorial
RNA repair as a novel to genetic therapy FREE
B A Sullenger
Abstract  |  Full text  |  PDF 461
Perspective
Politically correct gene therapy? A "clean environment" improves gene delivery to the brain! FREE
P R Lowenstein, C E Thomas & M G Castro
Abstract  |  Full text  |  PDF 463
Papers
Utilization of variant-type of human alpha-fetoprotein promoter in gene therapy targeting for hepatocellular carcinoma FREE
H Ishikawa, K Nakata, F Mawatari, T Ueki, S Tsuruta, A Ido, K Nakao, Y Kato, N Ishii & K Eguchi
Abstract  |  Full text  |  PDF 465
Variation in the immune response to adenoviral vectors in the brain: influence of mouse strain, environmental conditions and priming FREE
Y Ohmoto, M J A Wood, H M Charlton, K Kajiwara, V H Perry & K J Wood
Abstract  |  Full text  |  PDF 471
Metabolic instability of plasmid DNA in the cytosol: a potential barrier to gene transfer FREE
D Lechardeur, K-J Sohn, M Haardt, P B Joshi, M Monck, R W Graham, B Beatty, J Squire, H O'Brodovich & G L Lukacs
Abstract  |  Full text  |  PDF 482
Murine MHC class II locus control region drives expression of human bold beta-glucocerebrosidase in antigen presenting cells of transgenic mice FREE
J Guy, R Willemsen, A Langeveld, F Grosveld & D Drabek
Abstract  |  Full text  |  PDF 498
Electropermeabilization of skeletal muscle enhances gene transfer in vivo FREE
I Mathiesen
Abstract  |  Full text  |  PDF 508
Adenoviral reporter gene transfer to the human trabecular meshwork does not alter aqueous humor outflow. Relevance for potential gene therapy of glaucoma FREE
T Borrás, L L Rowlette, S C Erzurum & D L Epstein
Abstract  |  Full text  |  PDF 515
Complete cure of established murine hepatocellular carcinoma is achievable by repeated injections of retroviruses carrying the herpes simplex virus thymidine kinase gene FREE
S Kuriyama, K Masui, M Kikukawa, T Sakamoto, T Nakatani, S Nagao, M Yamazaki, H Yoshiji, H Tsujinoue, H Fukui, T Yoshimatsu & K Ikenaka
Abstract  |  Full text  |  PDF 525
The extra- and intracellular barriers to lipid and adenovirus-mediated pulmonary gene transfer in native sheep airway epithelium FREE
C Kitson, B Angel, D Judd, S Rothery, N J Severs, A Dewar, L Huang, S C Wadsworth, S H Cheng, D M Geddes & E W F W Alton
Abstract  |  Full text  |  PDF 534
Enhanced pancreatic tumor regression by a combination of adenovirus and retrovirus-mediated delivery of the herpes simplex virus thymidine kinase gene FREE
M Carrió, A Romagosa, E Mercadé, A Mazo, M Nadal, A-M Gómez-Foix & C Fillat
Abstract  |  Full text  |  PDF 547
Adenoviral delivery of CTLA4Ig into myeloid dendritic cells promotes their in vitro tolerogenicity and survival in allogeneic recipients FREE
L Lu, A Gambotto, W-C Lee, S Qian, C A Bonham, P D Robbins & A W Thomson
Abstract  |  Full text  |  PDF 554
Hepatoma-specific antitumor activity of an albumin enhancer/promoter regulated herpes simplex virus in vivo FREE
S-I Miyatake, S Tani, F Feigenbaum, P Sundaresan, H Toda, O Narumi, H Kikuchi, N Hashimoto, M Hangai, R L Martuza & S D Rabkin
Abstract  |  Full text  |  PDF 564
Macrophage inflammatory protein-2 gene therapy attenuates adenovirus- and acetaminophen-mediated hepatic injury FREE
C M Hogaboam, K J Simpson, S W Chensue, M L Steinhauser, N W Lukacs, J Gauldie, R M Strieter & S L Kunkel
Abstract  |  Full text  |  PDF 573
Dynamic changes in the characteristics of cationic lipidic vectors after exposure to mouse serum: implications for intravenous lipofection FREE
S Li, W-C Tseng, D Beer Stolz, S-P Wu, S C Watkins & L Huang
Abstract  |  Full text  |  PDF 585
PEGylated DNA/transferrin-PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery FREE
M Ogris, S Brunner, S Schüller, R Kircheis & E Wagner
Abstract  |  Full text  |  PDF 595
Transfer of the murine interleukin-12 gene in vivo by a Semliki Forest virus vector induces B16 tumor regression through inhibition of tumor blood vessel formation monitored by Doppler ultrasonography FREE
C Asselin-Paturel, N Lassau, J-M Guinebretière, J Zhang, F Gay, F Bex, S Hallez, J Leclere, P Peronneau, F Mami-Chouaib & S Chouaib
Abstract  |  Full text  |  PDF 606
Design of a muscle cell-specific expression vector utilising human vascular smooth muscle alpha-actin regulatory elements FREE
M-C Keogh, D Chen, J F Schmitt, U Dennehy, V V Kakkar & N R Lemoine
Abstract  |  Full text  |  PDF 616
Co-delivery of T helper 1-biasing cytokine genes enhances the efficacy of gene gun immunization of mice: studies with the model tumor antigen bold beta-galactosidase and the BALB/c Meth A p53 tumor-specific antigen FREE
T Tüting, A Gambotto, P D Robbins, W J Storkus & A B DeLeo
Abstract  |  Full text  |  PDF 629
Inhibition of adenovirus-mediated gene transfer by bronchoalveolar lavage fluid FREE
A Bastian & B Bewig
Abstract  |  Full text  |  PDF 637
Factors affecting blood clearance and in vivo distribution of polyelectrolyte complexes for gene delivery FREE
P R Dash, M L Read, L B Barrett, M A Wolfert & L W Seymour
Abstract  |  Full text  |  PDF 643
Lipoplex size is a major determinant of in vitro lipofection efficiency FREE
P C Ross & S W Hui
Abstract  |  Full text  |  PDF 651
Inhibition of HIV-1 by an anti-integrase single-chain variable fragment (SFv): delivery by SV40 provides durable protection against HIV-1 and does not require selection FREE
M BouHamdan, L-X Duan, R J Pomerantz & D S Strayer
Abstract  |  Full text  |  PDF 660
Efficient CFTR expression from AAV vectors packaged with promoters - the second generation FREE
D Wang, H Fischer, L Zhang, P Fan, R X Ding & J Dong
Abstract  |  Full text  |  PDF 667
Enhancement of calcium phosphate-mediated transfection by inclusion of adenovirus in coprecipitates FREE
J H Lee & M J Welsh
Abstract  |  Full text  |  PDF 676
Brief communication
Gene delivery to the myocardium by intrapericardial injection FREE
Y Fromes, A Salmon, X Wang, H Collin, A Rouche, A Hagège, K Schwartz & M Y Fiszman
Abstract  |  Full text  |  PDF 683
In vivo targeted gene transfer into liver cells mediated by a novel galactosyl-D-lysine/D-serine copolymer FREE
S Hisayasu, M Miyauchi, K Akiyama, T Gotoh, S Satoh & T Shimada
Abstract  |  Full text  |  PDF 689
Antigen-specific membrane fusion mediated by the haemagglutinin protein of influenza A virus: separation of attachment and fusion functions on different molecules FREE
S M Patterson, R Swainsbury & E G Routledge
Abstract  |  Full text  |  PDF 694
5-Azacytidine prevents transgene methylation in vivo FREE
M Di Ianni, A Terenzi, K Perruccio, R Ciurnelli, F Lucheroni, R Benedetti, M F Martelli & A Tabilio
Abstract  |  Full text  |  PDF 703
April 1999, Volume 6, Number 4
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