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| February 1998, Volume 5, Number 2, Pages 160-165 |
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| Paper |
| Enhancement of replication of genetically engineered herpes simplex viruses by ionizing radiation: a new paradigm for destruction of therapeutically intractable tumors |
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| S J Advani1, G S Sibley1, P Y Song1, D E Hallahan1, Y Kataoka1, B Roizman2 and R R Weichselbaum1 |
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1The Department of Radiation and Cellular Oncology, The University of Chicago Hospitals, Chicago, IL, USA
2The Marjorie B Kovler Viral Oncology Laboratories, The University of Chicago, Chicago, IL, USA
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| Abstract |
| Human U-87 malignant glioma xenografts in mice were exposed to ionizing radiation, inoculated with a herpes simplex virus 1 mutant R3616 lacking both copies of the  134.5 gene, or received both virus and radiation. Dual treatment caused a significantly greater reduction in volume or total regression of tumors than either radiation or infection alone. The significantly enhanced oncolytic effects of the combined treatment correlate with two- to five-fold enhanced replication in irradiated tumor cells than in tumors receiving virus only. In addition, in situ hybridization with viral DNA probes showed that infected tumor cells were the dominant landscape of irradiated tumors and much less apparent in the nonirradiated tumors administered this virus. |
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| Keywords |
| malignant gliomas; mouse models; attenuated herpesviruses |
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| Received 23 May 1997; accepted 7 August 1997 |
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| February 1998, Volume 5, Number 2, Pages 160-165 |
| Table of contents Previous Abstract Next Article PDF |
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