TABLE OF CONTENTS
Volume 16, Issue 5 (May 2009)
News and Commentary
SiRNAs and innate immunity
Innate Immunity confounds the clinical efficacy of small interfering RNAs (siRNAs) FREE
J J Rossi
Gene Ther 16: 579-580; advance online publication, March 5, 2009; doi:10.1038/gt.2009.26
Review
Progress and prospects: techniques for site-directed mutagenesis in animal models
Z Yan, X Sun and J F Engelhardt
Gene Ther 16: 581-588; advance online publication, February 19, 2009; doi:10.1038/gt.2009.16
Original Articles
A 16-bp RBE element mediated Rep-dependent site-specific integration in AAVS1 transgenic mice for expression of hFIX
Z X Xu, J Z Chen, Y B Yue, J Q Zhang, Z H Li, D M Feng, Z C Ruan, L Tian, J L Xue, Q J Wang and W Jia
Gene Ther 16: 589-595; advance online publication, February 26, 2009; doi:10.1038/gt.2009.9
Transfer of mRNA encoding recombinant immunoreceptors reprograms CD4+ and CD8+ T cells for use in the adoptive immunotherapy of cancer
K Birkholz, A Hombach, C Krug, S Reuter, M Kershaw, E Kämpgen, G Schuler, H Abken, N Schaft and J Dörrie
Gene Ther 16: 596-604; advance online publication, January 22, 2009; doi:10.1038/gt.2008.189
Validation of a mutated PRE sequence allowing high and sustained transgene expression while abrogating WHV-X protein synthesis: application to the gene therapy of WAS
M A Zanta-Boussif, S Charrier, A Brice-Ouzet, S Martin, P Opolon, A J Thrasher, T J Hope and A Galy
Gene Ther 16: 605-619; advance online publication, March 5, 2009; doi:10.1038/gt.2009.3
Rapid 
TCR-mediated responses in 
T cells transduced with cancer-specific TCR genes
A Hiasa, H Nishikawa, M Hirayama, S Kitano, S Okamoto, H Chono, S S Yu, J Mineno, Y Tanaka, N Minato, I Kato and H Shiku
Gene Ther 16: 620-628; advance online publication, February 26, 2009; doi:10.1038/gt.2009.6
Eight-year safety follow-up of coronary artery disease patients after local intracoronary VEGF gene transfer
M Hedman, K Muona, A Hedman, A Kivelä, M Syvänne, J Eränen, A Rantala, J Stjernvall, M S Nieminen, J Hartikainen and S Ylä-Herttuala
Gene Ther 16: 629-634; advance online publication, February 12, 2009; doi:10.1038/gt.2009.4
Control by pulse parameters of DNA electrotransfer into solid tumors in mice
M Cemazar, M Golzio, G Sersa, P Hojman, S Kranjc, S Mesojednik, M-P Rols and J Teissie
Gene Ther 16: 635-644; advance online publication, February 12, 2009; doi:10.1038/gt.2009.10
Intravenous transferrin, RGD peptide and dual-targeted nanoparticles enhance anti-VEGF intraceptor gene delivery to laser-induced CNV
S R Singh, H E Grossniklaus, S J Kang, H F Edelhauser, B K Ambati and U B Kompella
Gene Ther 16: 645-659; advance online publication, February 5, 2009; doi:10.1038/gt.2008.185
Herpes simplex virus vector-mediated gene delivery of glutamic acid decarboxylase reduces detrusor overactivity in spinal cord-injured rats
M Miyazato, K Sugaya, W F Goins, D Wolfe, J R Goss, M B Chancellor, W C de Groat, J C Glorioso and N Yoshimura
Gene Ther 16: 660-668; advance online publication, February 19, 2009; doi:10.1038/gt.2009.5
Oncolytic virus therapy for pancreatic cancer using the adenovirus library displaying random peptides on the fiber knob
T Nishimoto, K Yoshida, Y Miura, A Kobayashi, H Hara, S Ohnami, K Kurisu, T Yoshida and K Aoki
Gene Ther 16: 669-680; advance online publication, February 19, 2009; doi:10.1038/gt.2009.1
Targeting central serotonergic neurons with lentiviral vectors based on a transcriptional amplification strategy
K Benzekhroufa, B-H Liu, A G Teschemacher and S Kasparov
Gene Ther 16: 681-688; advance online publication, February 12, 2009; doi:10.1038/gt.2009.7
Dendritic cells and T cells deliver oncolytic reovirus for tumour killing despite pre-existing anti-viral immunity
E J Ilett, R J Prestwich, T Kottke, F Errington, J M Thompson, K J Harrington, H S Pandha, M Coffey, P J Selby, R G Vile and A A Melcher
Gene Ther 16: 689-699; advance online publication, March 12, 2009; doi:10.1038/gt.2009.29
Short Communication
Pseudotyping lentiviral vectors with the wild-type measles virus glycoproteins improves titer and selectivity
S Funke, I C Schneider, S Glaser, M D Mühlebach, T Moritz, R Cattaneo, K Cichutek and C J Buchholz
Gene Ther 16: 700-705; advance online publication, February 12, 2009; doi:10.1038/gt.2009.11
