FIGURE 6
FROM:
Novel anti-VEGF chimeric molecules delivered by AAV vectors for inhibition of retinal neovascularization
P Pechan, H Rubin, M Lukason, J Ardinger, E DuFresne, W W Hauswirth, S C Wadsworth and A Scaria
BACK TO ARTICLEFigure 6.
Adeno-associated virus (AAV)-mediated delivery of sFLT01 inhibits retinal neovascularization in the murine oxygen-induced retinopathy (OIR) model. The eyes of newborn mice were treated with a single intravitreal injection of 1.1 
109 drps of AAV2.sFLT01 vector into the left eye. The number of endothelial cell nuclei internal to the inner limiting membrane in the treated (left) eye was compared to the contralateral (right) eye. Data in both groups, AAV.sFLT01 (n=43) and control (n=26), are expressed as percentage of neovascularization of untreated (right) eyes (mean
s.d.). The difference was found to be statistically significant by Student's t-test (P<0.0009; as compared to the untreated contralateral eye).
