Gene Therapy

FIGURE 9

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Adenovirus-mediated overexpression of a gene prevents hearing loss and progressive inner hair cell loss after transient cochlear ischemia in gerbils

N Hakuba, K Watabe, J Hyodo, T Ohashi, Y Eto, M Taniguchi, L Yang, J Tanaka, R Hata and K Gyo

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Figure 9.

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Changes in the CAP threshold following transient cochlear ischemia. The CAP threshold before vertebral artery occlusion was defined as 0-dB. In the Ad-GDNF group, the CAP threshold recovered to the pre-ischemic level within 1 day after reperfusion. The average increase in the CAP threshold on the seventh day was significantly less in the Ad-GDNF group than in the Ad-LacZ or artificial perilymph group (*P<0.05, **P<0.01, respectively). All values are presented as the meanplusminuss.d. Statistical analysis consisted of two-way ANOVA followed by Dunnett's multiple comparison test.

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