Gene Therapy

FIGURE 7

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Adenovirus-mediated overexpression of a gene prevents hearing loss and progressive inner hair cell loss after transient cochlear ischemia in gerbils

N Hakuba, K Watabe, J Hyodo, T Ohashi, Y Eto, M Taniguchi, L Yang, J Tanaka, R Hata and K Gyo

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Figure 7.

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Changes in the CAP threshold after virus inoculation. CAP threshold after injection of Ad-GDNF vector, Ad-LacZ vector, or artificial perilymph at a rate of 0.5 mul/min for 4 min into the cochlea. The CAP threshold before vertebral artery occlusion was defined as 0 dB. There were no significant differences among the three groups, suggesting that the virus has no toxic effects. All values are presented as the meanplusminuss.d. Statistical analysis consisted of two-way ANOVA followed by Dunnett's multiple comparison test.

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