The Editors of Gene Therapy are delighted to share with you an Editor's Choice selection of key papers that highlight some of the best current research published in the journal. These papers showcase the breadth of scope and coverage that Gene Therapy consistently deliver to its readers, and have been selected because readers of the journal will find them particularly interesting or useful. The Editor's Choice article from the current issues will be freely accessible for one month.



Optimization of adeno-associated virus vector-mediated gene transfer to the respiratory tract

F Kurosaki, R Uchibori, N Mato, Y Sehara, Y Saga, M Urabe, H Mizukami, Y Sugiyama and A Kume

Gene Ther 24: 290-297; advance online publication, April 13, 2017; doi:10.1038/gt.2017.19

MR-guided parenchymal delivery of adeno-associated viral vector serotype 5 in non-human primate brain

L Samaranch, B Blits, W San Sebastian, P Hadaczek, J Bringas, V Sudhakar, M Macayan, P J Pivirotto, H Petry and K S Bankiewicz

Gene Ther 24: 253-261; advance online publication, March 16, 2017; doi:10.1038/gt.2017.14

Graphene materials as 2D non-viral gene transfer vector platforms

M Vincent, I de Lázaro and K Kostarelos

Gene Ther 24: 123-132; advance online publication, January 5, 2017; doi:10.1038/gt.2016.79

Conditional control of suicide gene expression in tumor cells with theophylline-responsive ribozyme

Y Zhang, J Wang, H Cheng, Y Sun, M Liu, Z Wu and R Pei

Gene Ther 24: 84-91; advance online publication, January 5, 2017; doi:10.1038/gt.2016.78

Interferon beta overexpression attenuates adipose tissue inflammation and high-fat diet-induced obesity and maintains glucose homeostasis

M Alsaggar, M Mills and D Liu

Gene Ther 24: 60-66; advance online publication, December 1, 2016; doi:10.1038/gt.2016.76



Tackling breast cancer chemoresistance with nano-formulated siRNA

S K Jones and O M Merkel

Gene Ther 23: 821-828; advance online publication, October 20, 2016; doi:10.1038/gt.2016.67

The LTR negative control region is a key element in MLV-mediated insertional mutagenesis

Y Ikawa, T Uchiyama, G J Jagadeesh and F Candotti

Gene Ther 23: 815-818; advance online publication, August 4, 2016; doi:10.1038/gt.2016.51

Long-term correction of Pompe disease in non-human primates with single dose of helper-dependent AdV vector

D P W Rastall, S S Seregin, Y A Aldhamen, L M Kaiser, C Mullins, A Liou, F Ing, C Pereria-Hicks, S Godbehere-Roosa, D Palmer, P Ng and A Amalfitano

Gene Therapy 23: 743-752; Published online, 21 July 2016; doi:10.1038/gt.2016.53

AAV9-mediated gene transfer of desmin ameliorates cardiomyopathy in desmin-deficient mice

M B Heckmann, R Bauer, A Jungmann, L Winter, K Rapti, K-H Strucksberg, C S Clemen, Z Li, R Schröder, H A Katus and O J Müller

Gene Ther 23: 673-679; advance online publication, May 12, 2016; doi:10.1038/gt.2016.40

Development of an AAV9 coding for a 3XFLAG-TALEfrat#8-VP64 able to increase in vivo the human frataxin in YG8R mice OPEN

P Chapdelaine, Gérard, N Sanchez, K Cherif, J Rousseau, D L Ouellet, D Jauvin and J P Tremblay

Gene Therapy 23: 606-614; Published online, 05 May 2016; doi:10.1038/gt.2016.36

CRISPR-on system for the activation of the endogenous human INS gene

C A Giménez, M Ielpi, A Mutto, L Grosembacher, P Argibay and F Pereyra-Bonnet

Gene Therapy 23: 543-547; Published online, 04 April 2016; doi:10.1038/gt.2016.28

Inducible scAAV2.GRE.MMP1 lowers IOP long-term in a large animal model for steroid-induced glaucoma gene therapy

T Borrás, L K Buie and M G Spiga

Gene Therapy 23: 438-449; Published online, 08 February 2016; doi:10.1038/gt.2016.14

IL-15/sIL-15Rα gene transfer induces weight loss and improves glucose homeostasis in obese mice

H Sun, Y Ma, M Gao and D Liu

Gene Therapy 23: 349-356; Published online, 16 January 2016; doi:10.1038/gt.2016.4

A novel intranuclear RNA vector system for long-term stem cell modification

Y Ikeda, A Makino, W E Matchett, S J Holditch, B Lu, A B Dietz and K Tomonaga

Gene Therapy 23: 256-262; Published online, 03 December 2015; doi:10.1038/gt.2015.108

Gene transfer of two entry inhibitors protects CD4+ T cell from HIV-1 infection in humanized mice

N Y Petit, C Baillou, A Burlion, K Dorgham, B Levacher, C Amiel, V Schneider, F M Lemoine, G Gorochov and G Marodon

Gene Therapy 23: 144-150; Published online, 21 October 2015; doi:10.1038/gt.2015.101

Noninvasive tracking of gene transcript and neuroprotection after gene therapy

J Ren, Y I Chen, C H Liu, P-C Chen, H Prentice, J-Y Wu and P K Liu

Gene Therapy 23: 1-9; Published online, 24 July 2015; doi:10.1038/gt.2015.81

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