Figure 11 - Anion-sensing ion channel 1 (ASIC1) is inhibited by amiloride and its derivatives.

Inhibition of ASIC1 action potential propagation is a function of the logarithmic concentration of the drug in the oocyte. The inward current is blocked by the administration of amiloride, benzamil, and ethylisopropyl-amiloride. (Source: Waldmann et al.,⁶⁵ with permission from Macmillan Publishers Ltd.)