Figure 10 - Acid-sensing ion channels (ASIC) function as proton-gated channels.


From the following article

Heartburn and esophageal pain

Robert Lee and Ravinder Mittal

GI Motility online (2006)

doi:10.1038/gimo75

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Left: A rapid change in pH from 7.4 to 6 results in inward currents measured at -70 mV in the xenopus oocyte. Right: A drop in pH results in proton transfer and action potential. The mean inward current (I) is measured over six experiments as compared to the maximum inward current (Imax). A significant change in inward current is seen at a mean pH (pHm) of 6.4. Beyond a pH of 6, there is little change in inward current. (Source: Waldmann et al.,65 with permission from Macmillan Publishers Ltd.)

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