Figure 7 - RhoA in LES tone and PGF2alpha-induced sustained contraction.

From the following article

Signal transduction in lower esophageal sphincter circular muscle

Piero Biancani and Karen M. Harnett

GI Motility online (2006)



a: In LES circular muscle cells, PGF2alpha caused a relatively rapid initial contraction that was maintained in excess of 20 minutes. In the presence of the Rho kinase inhibitor Y27632 the initial phase of contraction in response to PGF2alpha was not affected. The sustained contraction, however, was almost abolished by Y27632, indicating that the initial and the sustained phase of contraction are mediated through different intracellular pathways. b: The Rho kinase inhibitor Y27632 reduced LES sustained contraction in response to PGF2alpha, confirming the participation of RhoA in maintenance-sustained contraction in muscle strips as well as in isolated muscle cells. (Source: Harnett et al.,3 with permission from the American Physiological Society.)

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