Figure 9 - Response characteristics of mucosal mechanosensitive afferent fibers.

Typical response characteristics of mucosal mechanosensitive afferent fibers of ferrets to bradykinin (a), serotonin (5-HT, b), prostaglandin E₂ (PGE₂, c), TRPV1 agonist capsaicin (d), and hydrochloric acid (HCl, e). Chemicals were applied topically on the mucosa after identification of the fiber's response to mechanical probing. In each panel, the top trace represents the firing frequency and the bottom trace is nerve action potentials. The responses to these chemicals are not from one mucosal afferent fiber. (Source: Page and Blackshaw,⁶⁴ with permission.)