1. ¹Tissue Typing Laboratory-7631, Department of Clinical Immunology, Rigshospitalet, Copenhagen, Denmark
2. ²Instituto de Genetica y Biologia Molecular, Facultad de Medicina e la Universidad de San Martin de Porres, Lima, Peru

Correspondence: Dr P Garred, Tissue Typing Laboratory–7631, Department of Clinical Immunology, Rigshospitalet, Blegdamsvej 9, DK, 2100 Copenhagen, Denmark. E-mail: garred@post5.tele.dk

Received 9 September 2005; Revised 29 November 2005; Accepted 29 November 2005; Published online 5 January 2006.

Abstract

Mannose-binding lectin (MBL) is a collagen-like serum protein that mediates activation of the complement system and is of importance for host defence. Common variant alleles situated both in the promoter and structural region of the human MBL gene (MBL2) influence the stability and the serum concentration of the protein. Epidemiological studies have suggested that genetically determined variation in MBL serum concentration influences the susceptibility to and the course of different types of infections, autoimmune, metabolic and cardiovascular diseases, but this is still a subject of debate. The fact that these genetic variations are very frequent indicates a dual role for MBL in host defence. In this survey, we summarize the current molecular understanding of human MBL genetics.