FIGURE 1
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Extended haplotypes and linkage disequilibrium in the IL1R1–IL1A–IL1B–IL1RN gene cluster: association with knee osteoarthritis
A J P Smith, L J Keen, M J Billingham, M J Perry, C J Elson, J R Kirwan, J E Sims, M Doherty, T D Spector and J L Bidwell
BACK TO ARTICLEFigure 1.
Organisation of the IL1R1–IL1A–IL1B–IL1RN gene cluster showing polymorphic nucleotide sequences. (a) Map of genes within the region, showing base positions on chromosome 2q according to the UCSC Human Genome Browser July 2003 Assembly (http://genome.cse.ucsc.edu/). Direction of transcription is shown beneath each gene by a horizontal arrow. (b) Exon–intron organisation of the IL1R1, IL1A, IL1B and IL1RN genes. Exons are shown as vertical lines or boxes. Exon : intron size ratios are shown to scale. For clarity, genes are not shown to scale: genomic sizes of genes are: IL1R1, 72.3 kb (14 exons: 1A, 1B, 1C, 2–11); IL1A, 10.55 kb (seven exons); IL1B, 7.03 kb (seven exons); IL1RN, 5.25 kb (four exons). Polymorphic nucleotide sequences examined in the IL1A, IL1B and IL1RN genes are shown. (c) Exon–intron organisation of the alternative IL1R1 promoters. Polymorphic nucleotide sequences are shown and those examined are denoted in bold typeface. TSS, transcription start site for the 1A promoter.
