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Polymorphisms in the interleukin-20 gene: relationships to plaque-type psoriasis

Genes & Immunity volume 5, pages 117–121 (2004)Cite this article

Abstract

We analyzed the frequency of single-nucleotide polymorphisms (SNPs) at positions −1053 (rs 2981572), 1380 (rs 2981573), 1462 (rs 2232360), and 3978 (rs 1518108) of the human interleukin-20 (IL-20) gene by tetraprimer ARMS-PCR method. A significant association between patients with psoriasis and the G allele at position −1053 (P<0.05) was established. The pairwise linkage disequilibrium (LD) matrix showed that the nearly complete LD was present within the polymorphisms at positions −1053, 1380, and 1462 of the IL-20 gene. We found that patients with plaque psoriasis had a higher frequency of the HT3 GAA haplotype (P<0.01, OR 2.341, 95% CI: 1.346–4.074) compared to the control group. Likewise, the HT3 GAA haplotype was associated with an increased risk of early-onset psoriasis (P<0.01, OR 2.305, 95% CI: 1.285–4.132), late onset of disease (P<0.01, OR 2.542, 95% CI: 1.266–5.102), familial psoriasis (P<0.02, OR 2.220, 95% CI: 1.249–3.945), and sporadic disease (P<0.01, OR 2.523, 95% CI: 1.390–4.580). Our data indicate that IL-20 gene polymorphisms should have a role in determining susceptibility to plaque-type psoriasis. The possible role of the studied SNPs in the regulation of the expression of IL-20 is unknown yet and needs further studies.

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Acknowledgements

This study was supported by the target based funding from the Estonian Ministry of Education Grant No. 0182128s02 (PARNH2128).

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Authors and Affiliations

  1. Department of Dermatology and Venerology, University of Tartu, Tartu, Estonia

    K Kingo & H Silm

  2. Department of Physiology, University of Tartu, Tartu, Estonia

    S Kõks & E Vasar

  3. Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia

    T Nikopensius

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  1. K Kingo
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Correspondence to S Kõks.

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Kingo, K., Kõks, S., Nikopensius, T. et al. Polymorphisms in the interleukin-20 gene: relationships to plaque-type psoriasis. Genes Immun 5, 117–121 (2004). https://doi.org/10.1038/sj.gene.6364046

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