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Genetic regulation of host responses to Salmonella infection in mice

Genes & Immunity volume 3, pages 381–393 (2002)Cite this article

Abstract

Salmonella spp are Gram-negative bacteria capable of infecting a wide range of host species, including humans, domesticated and wild mammals, reptiles, birds and insects. The outcome of an encounter between Salmonella and its host is dependent upon multiple factors including the host genetic background. To facilitate the study of the genetic factors involved in resistance to this pathogen, mouse models of Salmonella infection have been developed and studied for years, allowing identification of several genes and pathways that may influence the disease outcome. In this review, we will cover some of the genes involved in mouse resistance to Salmonella that were identified through the study of congenic mouse strains, cloning of spontaneous mouse mutations, use of site-directed mutagenesis or quantitative trait loci analysis. In parallel, the relevant information pertaining to genes involved in resistance to Salmonella in humans will be discussed.

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Acknowledgements

We thank Ellen Bushman and Silvia Vidal for a critical reading of the manuscript. Danielle Malo is an investigator of the Canadian Institutes for Health Research and an International Research Scholar of the Howard Hughes Medical Institute.

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  1. Department of Human Genetics, McGill University Health Center, Montréal, Québec, Canada

    M-F Roy & D Malo

  2. Department of Medicine, McGill University Health Center, Montréal, Québec, Canada

    D Malo

  3. Center for the Study of Host Resistance, McGill University Health Center, Montréal, Québec, Canada

    M-F Roy & D Malo

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  1. M-F Roy
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Correspondence to D Malo.

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Roy, MF., Malo, D. Genetic regulation of host responses to Salmonella infection in mice. Genes Immun 3, 381–393 (2002). https://doi.org/10.1038/sj.gene.6363924

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  • DOI: https://doi.org/10.1038/sj.gene.6363924

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