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| September 2002, Volume 3, Number 6, Pages 368-372 |
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| Full Paper |
| A weak association of HLA-B*2702 with Behçet's disease |
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| A Gül1, F A Uyar2, M Inanç1, L Ocal1, J H Barrett3, O Aral1, M Koniçe1 and G Saruhan-Direskeneli2 |
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1Division of Rheumatology, Department of Internal Medicine, Istanbul School of Medicine, University of Istanbul, Istanbul, Turkey
2Department of Physiology, Istanbul School of Medicine, University of Istanbul, Istanbul, Turkey
3ARC Epidemiology Unit, University of Manchester, Manchester, UK
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Correspondence to: Dr A Gül, Division of Rheumatology, Department of Internal Medicine, Istanbul School of Medicine, Capa, 34390 Istanbul, Turkey. E-mail: agul@istanbul.edu.tr | |
This study was supported by University of Istanbul Research Funds, Project No. 1076/031297. |
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| Abstract |
| This study aimed to analyse the association of HLA-B alleles other than -B51 with Behçet's disease (BD). We also investigated the frequency of HLA-B alleles sharing the same natural killer cell immunoglobulin-like receptor (KIR) binding sequence with HLA-B51. Broad-genotyping of HLA-B locus by PCR-SSOP in 174 Turkish BD patients and 191 healthy controls confirmed the strong association of B*51 with BD (60.9% in BD patients, 24.6% in healthy controls, OR = 4.78). No other HLA-B allele was identified showing an association with BD after adjusting for multiple testing or by using relative predispositional effects (RPE) analysis after the deletion of B*51. HLA-B alleles reacting with the sequence specific oligonucleotide probe 23, which corresponds to the KIR binding site of B*51, were found to be positive in 127 BD patients (73%) and 90 controls (47%) (OR = 3.03, 95% CI 2-4.7). The repeated RPE analysis after separating HLA-B alleles carrying B51-KIR binding sequence as distinct alleles within a broad-type allele group revealed B*2702 allele as the only allele showing an association with BD after the deletion of B*51. Selective increase of B*2702, the only B*27 allele carrying the same KIR binding sequence with B*51, warrants investigation of the possibility of interaction of HLA molecules with KIRs on NK or other T cells in the pathogenesis of BD. Genes and Immunity (2002) 3, 368-372. doi:10.1038/sj.gene.6363863 |
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| Keywords |
| Behçet's disease; HLA-B*2702; HLA-B51; immunoglobulin-like killer inhibitory receptor (KIR); NK cell; relative predispositional effects; allelic association |
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| Received 23 August 2001; revised 1 February 2002; accepted 1 February 2002 |
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| September 2002, Volume 3, Number 6, Pages 368-372 |
| Table of contents Previous Abstract Next Full text PDF |
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