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LACC1 polymorphisms in inflammatory bowel disease and juvenile idiopathic arthritis

Genes & Immunity volume 17, pages 261–264 (2016)Cite this article

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Abstract

The function of the Laccase domain-containing 1 (LACC1) gene is unknown, but genetic variation at this locus has been reported to consistently affect the risk of Crohn's disease (CD) and leprosy. Recently, a LACC1 missense mutation was found in patients suffering from monogenic forms of CD, but also systemic juvenile idiopathic arthritis. We tested the hypothesis that LACC1 single nucleotide polymorphisms (SNPs), in addition to CD, are associated with juvenile idiopathic arthritis (JIA, non-systemic), and another major form of inflammatory bowel disease, ulcerative colitis (UC). We selected 11 LACC1 tagging SNPs, and tested their effect on disease risk in 3855 Swedish individuals from three case–control cohorts of CD, UC and JIA. We detected false discovery rate corrected significant associations with individual markers in all three cohorts, thereby expanding previous results for CD also to UC and JIA. LACC1’s link to several inflammatory diseases suggests a key role in the human immune system and justifies further characterization of its function(s).

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Acknowledgements

MD’s work was supported by grants from the Swedish Research Council (Vetenskapsrådet). The JIA cohort collection and work by RS and ES were supported by a Stockholm County regional grant (ALF, 20120637), Juvenile Arthritis Bio Bank Astrid Lindgren’s Children Hospital (JABBA) and Berth von Kantzow’s foundation to HEH.

Author contributions

Conceived and designed the experiments: GA and MD. Performed the experiments: GA. Analyzed the data: GA, FH and FB. Clinical characterization and sample collection/preparation: RS, JH, LT, ASE, HEH and ES. Wrote the paper: GA, LV and MD. All authors read and approved the final manuscript.

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Authors and Affiliations

  1. Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden

    G Assadi, F Hadizadeh, L Vesterlund, F Bonfiglio & M D'Amato

  2. Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

    R Saleh & H E Harris

  3. Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden

    J Halfvarson

  4. Gastrocentrum, Karolinska University Hospital, StockhoCrohn’slm, Sweden

    L Törkvist

  5. Department of Internal Medicine, Gatroenterology Unit, Sahlgren’s University Hospital/Östra, Göteborg, Sweden

    A S Eriksson

  6. Department of Women’s and Children’s Health, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

    E Sundberg

  7. BioCruces Health Research Institute and IKERBASQUE, Basque Foundation for Science, Bilbao, Spain

    M D'Amato

Authors
  1. G Assadi
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  2. R Saleh
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  3. F Hadizadeh
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  4. L Vesterlund
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  5. F Bonfiglio
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  6. J Halfvarson
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  7. L Törkvist
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  8. A S Eriksson
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  9. H E Harris
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  10. E Sundberg
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  11. M D'Amato
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Corresponding author

Correspondence to G Assadi.

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The authors declare no conflict of interest.

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Assadi, G., Saleh, R., Hadizadeh, F. et al. LACC1 polymorphisms in inflammatory bowel disease and juvenile idiopathic arthritis. Genes Immun 17, 261–264 (2016). https://doi.org/10.1038/gene.2016.17

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  • DOI: https://doi.org/10.1038/gene.2016.17

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