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Overview of the Type I Diabetes Genetics Consortium

Genes & Immunity volume 10, pages S1–S4 (2009)Cite this article

Abstract

The Type I Diabetes Genetics Consortium (T1DGC) is an international, multicenter research program with two primary goals. The first goal is to identify genomic regions and candidate genes whose variants modify an individual's risk of type I diabetes (T1D) and help explain the clustering of the disease in families. The second goal is to make research data available to the research community and to establish resources that can be used by, and that are fully accessible to, the research community. To facilitate the access to these resources, the T1DGC has developed a Consortium Agreement (http://www.t1dgc.org) that specifies the rights and responsibilities of investigators who participate in Consortium activities. The T1DGC has assembled a resource of affected sib-pair families, parent–child trios, and case–control collections with banks of DNA, serum, plasma, and EBV-transformed cell lines. In addition, both candidate gene and genome-wide (linkage and association) studies have been performed and displayed in T1DBase (http://www.t1dbase.org) for all researchers to use in their own investigations. In this supplement, a subset of the T1DGC collection has been used to investigate earlier published candidate genes for T1D, to confirm the results from a genome-wide association scan for T1D, and to determine associations with candidate genes for other autoimmune diseases or with type II diabetes that may be involved with β-cell function.

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Acknowledgements

This research uses resources provided by the Type I Diabetes Genetics Consortium, a collaborative clinical study sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute of Allergy and Infectious Diseases (NIAID), National Human Genome Research Institute (NHGRI), National Institute of Child Health and Human Development (NICHD), and Juvenile Diabetes Research Foundation International (JDRF) and supported by U01 DK062418. Further support was provided by a grant from the NIDDK (DK46635) to PC and a joint JDRF and Wellcome Trust grant to the Diabetes and Inflammation Laboratory at Cambridge, which also received support from the National Institute for Health Research Cambridge Biomedical Research Centre. Genotyping was performed by the Center for Inherited Disease Research (CIDR). CIDR is fully funded through a federal contract from the National Institutes of Health to the Johns Hopkins University, contract no. N01-HG-65403.

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Authors and Affiliations

  1. Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA

    S S Rich & P Concannon

  2. Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA

    S S Rich

  3. Division of Diabetes, Endocrinology, and Metabolic Diseases, The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD, USA

    B Akolkar

  4. Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA

    P Concannon

  5. Roche Molecular Systems, Pleasanton, CA, USA

    H Erlich

  6. Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA

    J E Hilner

  7. Inserm U730, Centre National de Génotypage, Evry, France

    C Julier

  8. Centre for Diabetes Research, The Western Australian Institute for Medical Research, and Centre for Medical Research, University of Western Australia, Perth, Australia

    G Morahan

  9. Steno Diabetes Center, Gentofte, Denmark

    J Nerup & F Pociot

  10. Juvenile Diabetes Research Foundation International, New York, NY, USA

    C Nierras

  11. Department of Medical Genetics, Cambridge Institute for Medical Research, Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK

    J A Todd

Authors
  1. S S Rich
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  2. B Akolkar
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  3. P Concannon
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  4. H Erlich
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  5. J E Hilner
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  6. C Julier
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  7. G Morahan
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  8. J Nerup
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  9. C Nierras
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  10. F Pociot
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  11. J A Todd
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Correspondence to S S Rich.

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Rich, S., Akolkar, B., Concannon, P. et al. Overview of the Type I Diabetes Genetics Consortium. Genes Immun 10 (Suppl 1), S1–S4 (2009). https://doi.org/10.1038/gene.2009.84

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