Nature Reviews Molecular Cell Biology 4, SS6–SS10 (2003) Review: Electron microscopy in cell biology: integrating structure and function Electron microscopy (EM) is at the highest-resolution limit of a spectrum of complementary morphological techniques. When combined with molecular detection methods, EM is the only technique with sufficient resolution to localize proteins to small membrane subdomains in the context of the cell. Recent procedural and technical developments have increasingly improved the power of EM as a cell-biological tool.
Abraham J. Koster1 and Judith Klumperman2
1Department of Molecular Cell Biology, Faculty of Biology and Institute of Biomembranes, 3584 CH Utrecht, The Netherlands.
2Department of Cell Biology, Center for Electron Microscopy, University Medical Center Utrecht and Institute of Biomembranes, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
email: j.klumperman@lab.azu.nl
Published online: 1
September 2003
doi:10.1038/nrm1194 |
