NPG library
Below is a selection of News and Views, Research Highlights, Reviews, Research Articles, Perspectives and Commentaries published by Nature Publishing group journals on the topic of antibacterials. Selected articles on this page are freely available from December 2006 to June 2007.
- Editorials
- Research Highlights
- News & Analysis
- Research Articles
- Reviews
- Perspectives & Commentaries
Editorials
Bacteria not welcome at the MRC?
doi:10.1038/nrmicro1332
Nature Reviews Microbiology 4, 2 (2006) FREE ACCESS
Coming clean
doi:10.1038/nchembio1205-349
Nature Chemical Biology 1, 349 (2005) FREE ACCESS
Staying ahead of the fourth horseman
John H. Rex
doi:10.1038/nrmicro989
Nature Reviews Microbiology 2, 684 (2004) FREE ACCESS
Research Highlights
Antibacterial discovery gets a shove
doi:10.1038/nbt1006-1233
Nature Biotechnology 24, 1233 (2006) FREE ACCESS
New antibiotic on the horizon?
Samantha Barton
doi:10.1038/nrmicro1471
Nature Reviews Microbiology 4, 571 (2006) FREE ACCESS
My enemy's enemy is my friend
Michael Eisenstein
doi:10.1038/nmeth0506-338b
Nature Methods 3, 338 (2006) FREE ACCESS
Pinpoint attack on resistance
Peter Kirkpatrick
doi:10.1038/nrd2022
Nature Reviews Drug Discovery 5, 284 (2006) FREE ACCESS
Holliday key to novel antibacterials?
Sheilagh Molloy
doi:10.1038/nrmicro1359
Nature Reviews Microbiology 4, 86-87 (2006) FREE ACCESS
Peptide power
Joanna Owens
doi:10.1038/nrd1910
Nature Reviews Drug Discovery 4, 957 (2005) FREE ACCESS
Accept some substitutes
Joanna Owens
doi:10.1038/nrd1859
Nature Reviews Drug Discovery 4, 812 (2005) FREE ACCESS
Antibacterial drugs: Tackling tuberculosis
Daniel Jones
doi:10.1038/nrd1645
Nature Reviews Drug Discovery 4, 103 (2005) FREE ACCESS
Pneumococcus forks out...
David O'Connell
doi:10.1038/nrmicro1105
Nature Reviews Microbiology 3, 99 (2005) FREE ACCESS
Natural defences
Shannon Amoils
doi:10.1038/nrmicro1017
Nature Reviews Microbiology 2, 769 (2004) FREE ACCESS
Diverse defence
Sheilagh Clarkson
doi:10.1038/nrmicro992
Nature Reviews Microbiology 5, 686 (2004) FREE ACCESS
Race against resistance
Jane Saunders
doi:10.1038/nrmicro849
Nature Reviews Microbiology 2, 183 (2004) FREE ACCESS
First predatory bacterium sequenced
Sheilagh Clarkson
doi:10.1038/nrmicro857
Nature Reviews Microbiology 2, 180 (2004) FREE ACCESS
Better the devil you know
Susan Jones
doi:10.1038/nrmicro836
Nature Reviews Microbiology 2, 85 (2004) FREE ACCESS
Stitching together naturally
Peter Kirkpatrick
doi:10.1038/nrd921
Nature Reviews Drug Discovery 1, 748 (2002) FREE ACCESS
News & Analysis
Microbiology: Antibiotic stops 'ping-pong' match
Eric D. Brown
doi:10.1038/441293a
Nature 441, 293-294 (2006) FREE ACCESS
Do targets limit antibiotic discovery?
Molly B Schmid
doi:10.1038/nbt0406-419
Nature Biotechnology 24, 419-420 (2006) FREE ACCESS
Uncultured antibiotic biosynthesis
doi:10.1038/nchembio1205-359
Nature Chemical Biology 1, 359 (2005) FREE ACCESS
Fresh from the pipeline: Tigecycline
Richard Wenzel, Guy Bate and Peter Kirkpatrick
doi:10.1038/nrd1857
Nature Reviews Drug Discovery FREE ACCESS 4, 809-810 (2005)
Acquisitions not a cure for antiinfectives
David Bradley
doi:10.1038/nrd1839
Nature Reviews Drug Discovery 4, 704-705 (2005) FREE ACCESS
Uninhibited antibiotic target discovery via chemical genetics
Keith Poole
doi:10.1038/nbt1204-1528
Nature Biotechnology 22, 1528-1529 (2004) FREE ACCESS
Fresh from the pipeline: Telithromycin
Aarti Raja, John Lebbos and Peter Kirkpatrick
doi:10.1038/nrd1502
Nature Reviews Drug Discovery 3, 733-734 (2004) FREE ACCESS
Phage-inspired antibiotics?
Steven Projan
doi:10.1038/nbt0204-167
Nature Biotechnology 22, 167-168 (2004) FREE ACCESS
Response: Phage offer a real alternative
Steven Projan
doi:10.1038/nbt0504-506
Nature Biotechnology 22, 506-507 (2004) FREE ACCESS
Fresh from the pipeline: Daptomycin
doi:10.1038/nrd1258
Nature Reviews Drug Discovery 2, 506-507 (2003) FREE ACCESS
Concerns raised over declining antiinfectives R&D
Jeffrey L. Fox
doi:10.1038/nbt904
Nature Biotechnology 21, 1255-1256 (2003) FREE ACCESS
Research Articles
Small molecules with antimicrobial activity against E. coli and P. aeruginosa identified by high-throughput screening
R De La Fuente, N D Sonawane, D Arumainayagam and A S Verkman
doi:10.1038/sj.bjp.0706873
British Journal of Pharmacology 149, 551-559 (2006) FREE ACCESS
Structural basis of lipid biosynthesis regulation in Gram-positive bacteria
Gustavo E Schujman, Marcelo Guerin, Alejandro Buschiazzo, Francis Schaeffer, Leticia I Llarrull, Georgina Reh, Alejandro J Vila, Pedro M Alzari and Diego de Mendoza
doi:10.1038/sj.emboj.7601284
The EMBO Journal 25, 4074-4083 (2006) FREE ACCESS
The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection
Milan Chromek, Zuzana Slamová, Peter Bergman, László Kovács, L'udmila Podracká, Ingrid Ehrén, Tomas Hökfelt, Gudmundur H Gudmundsson, Richard L Gallo, Birgitta Agerberth and Annelie Brauner
doi:10.1038/nm1407
Nature Medicine 12, 636-641 (2006) FREE ACCESS
Platensimycin is a selective FabF inhibitor with potent antibiotic properties
Jun Wang, Stephen M. Soisson, Katherine Young, Wesley Shoop, Srinivas Kodali, Andrew Galgoci, Ronald Painter, Gopalakrishnan Parthasarathy, Yui S. Tang, Richard Cummings, Sookhee Ha, Karen Dorso, Mary Motyl, Hiranthi Jayasuriya, John Ondeyka, Kithsiri Herath, Chaowei Zhang, Lorraine Hernandez, John Allocco, Ángela Basilio, José R. Tormo, Olga Genilloud, Francisca Vicente, Fernando Pelaez, Lawrence Colwell, Sang Ho Lee, Bruce Michael, Thomas Felcetto, Charles Gill, Lynn L. Silver, Jeffery D. Hermes, Ken Bartizal, John Barrett, Dennis Schmatz, Joseph W. Becker, Doris Cully and Sheo B. Singh
doi:10.1038/nature04784
Nature 441, 358-361 FREE ACCESS
Dysregulation of bacterial proteolytic machinery by a new class of antibiotics
Heike Brötz-Oesterhelt, Dieter Beyer, Hein-Peter Kroll, Rainer Endermann, Christoph Ladel, Werner Schroeder, Berthold Hinzen, Siegfried Raddatz, Holger Paulsen, Kerstin Henninger, Julia E Bandow, Hans-Georg Sahl and Harald Labischinski
doi:10.1038/nm1306
Nature Medicine 11, 1082-1087 (2005) FREE ACCESS
High-throughput generation of small antibacterial peptides with improved activity
Kai Hilpert, Rudolf Volkmer-Engert, Tess Walter and Robert E W Hancock
doi:10.1038/nbt1113
Nature Biotechnology 23, 1008-1012 (2005) FREE ACCESS
Antimicrobial drug discovery through bacteriophage genomics
Jing Liu, Mohammed Dehbi, Greg Moeck, Francis Arhin, Pascale Bauda, Dominique Bergeron, Mario Callejo, Vincent Ferretti, Nhuan Ha, Tony Kwan, John McCarty, Ramakrishnan Srikumar, Dan Williams, Jinzi J Wu, Philippe Gros, Jerry Pelletier and Michael DuBow
doi:10.1038/nbt932
Nature Biotechnology 22, 185-191 (2004) FREE ACCESS
Structural analysis of the sialyltransferase CstII from Campylobacter jejuni in complex with a substrate analog
Cecilia P C Chiu, Andrew G Watts, Luke L Lairson, Michel Gilbert, Daniel Lim, Warren W Wakarchuk, Stephen G Withers and Natalie C J Strynadka
doi:10.1038/nsmb720
Nature Structural & Molecular Biology 11, 163-170 (2004) FREE ACCESS
The unfolding of the P pili quaternary structure by stretching is reversible, not plastic
doi:10.1038/sj.embor.7400310
EMBO Reports 6, 52-56 (2005)
Antibiotic optimization via in vitro glycorandomization
Xun Fu, Christoph Albermann, Jiqing Jiang, Jianchun Liao, Changsheng Zhang and Jon S Thorson
doi:10.1038/nbt909
Nature Biotechnology 21, 1467-1469 (2003)
An engineered multidomain bactericidal peptide as a model for targeted antibiotics against specific bacteria
Xiao-Qing Qiu, He Wang, Xiao-Fong Lu, Jie Zhang, Sheng-Fu Li, Gang Cheng, Lin Wan, Li Yang, Jun-Yong Zuo, Yu-Qi Zhou, Hai-Yun Wang, Xin Cheng, Su-Hua Zhang, Zheng-Rong Ou, Zi-Cheng Zhong, Jing-Qiu Cheng, You-Ping Li and George Y Wu
doi:10.1038/nbt913
Nature Biotechnology 21, 1480-1485 (2003) FREE ACCESS
Therapeutic effect of DNA vaccines combined with chemotherapy in a latent infection model after aerosol infection of mice with Mycobacterium tuberculosis
S-J Ha, B-Y Jeon, S-C Kim, D-J Kim, M-K Song, Y-C Sung & S-N Cho
doi:10.1038/sj.gt.3302057
Gene Therapy 10, 1592-1599 (2003) FREE ACCESS
Horizontal transfer of drug-resistant aminoacyl-transfer-RNA synthetases of anthrax and Gram-positive pathogens
James R. Brown, Daniel Gentry, Julie A. Becker, Karen Ingraham, David J. Holmes and Michael J. Stanhope
doi:10.1038/sj.embor.embor881
EMBO Reports 4, 692-698 (2003)
Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis
Natalia Ivanova, Alexei Sorokin, Iain Anderson, Nathalie Galleron, Benjamin Candelon, Vinayak Kapatral, Anamitra Bhattacharyya, Gary Reznik, Natalia Mikhailova, Alla Lapidus, Lien Chu, Michael Mazur, Eugene Goltsman, Niels Larsen, Mark D'Souza, Theresa Walunas, Yuri Grechkin, Gordon Pusch, Robert Haselkorn, Michael Fonstein, S. Dusko Ehrlich, Ross Overbeek and Nikos Kyrpides
doi:10.1038/nature01582
Nature 423, 87-91 (2003)
Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin
Nita H. Salzman, Dipankar Ghosh, Kenneth M. Huttner, Yvonne Paterson and Charles L. Bevins
doi:10.1038/nature01520
Nature 422, 522-526 (2003)
Structural basis for oligosaccharide-mediated adhesion of Pseudomonas aeruginosa in the lungs of cystic fibrosis patients
Edward Mitchell, Corinne Houles, Dvora Sudakevitz, Michaela Wimmerova, Catherine Gautier, Serge Pérez, Albert M. Wu, Nechama Gilboa-Garber and Anne Imberty
doi:10.1038/nsb865
Nature Structural & Molecular Biology 9, 918-921 (2002) FREE ACCESS
Biomimetic synthesis and optimization of cyclic peptide antibiotics
Rahul M. Kohli, Christopher T. Walsh and Michael D. Burkart
doi:10.1038/nature00907
Nature 418, 658-661 (2002) FREE ACCESS
Genetic engineering of aminodeoxyhexose biosynthesis in Streptomyces fradiae
Andrew R. Butler, Neil Bate, Douglas E. Kiehl, Herbert A. Kirst and Eric Cundliffe
doi:10.1038/nbt0702-713
Nature Biotechnology 20, 713-716 (2002)
An array of target-specific screening strains for antibacterial discovery
Joseph A. DeVito, Jonathan A. Mills, Veronica G. Liu, Anjana Agarwal, Christine F. Sizemore, Zhongjie Yao, Daniel M. Stoughton, Maria Grazia Cappiello, Maria D.F.S. Barbosa, Lorie A. Foster and David L. Pompliano
doi:10.1038/nbt0502-478
Nature Biotechnology 20, 478-483 (2002)
Substrate promiscuity of an aminoglycoside antibiotic resistance enzyme via target mimicry
Desiree H. Fong and Albert M. Berghuis
doi:10.1093/emboj/21.10.2323
The EMBO Journal 21, 2323-2331 (2002)
The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein
Marie Gottar, Vanessa Gobert, Tatiana Michel, Marcia Belvin, Geoffrey Duyk, Jules A. Hoffmann, Dominique Ferrandon and Julien Royet
doi:10.1038/nature734
Nature 5, 640-644 (2002)
Antimicrobials: Peptide antibiotics in mast cells of fish
Umaporn Silphaduang and Edward J. Noga
doi:10.1038/35104690
Nature 414, 268-269 (2001) FREE ACCESS
Bactericidal antisense effects of peptide-PNA conjugates
Liam Good, Satish Kumar Awasthi, Rikard Dryselius, Ola Larsson and Peter E. Nielsen
doi:10.1038/86753
Nature Biotechnology 19, 360-364 (2001)
Antibacterial agents based on the cyclic D,L-
-peptide architecture
Sara Fernandez-Lopez, Hui-Sun Kim, Ellen C. Choi, Mercedes Delgado, Juan R. Granja, Alisher Khasanov, Karin Kraehenbuehl, Georgina Long, Dana A. Weinberger, Keith M. Wilcoxen and M. Reza Ghadiri
doi:10.1038/35086601
Nature 412, 452-455 (2001) FREE ACCESS
Reviews
The co-evolution of host cationic antimicrobial peptides and microbial resistance
Andreas Peschel and Hans-Georg Sahl
doi:10.1038/nrmicro1441
Nature Reviews Microbiology 4, 529-536 (2006) FREE ACCESS
Lipid II as a target for antibiotics
Eefjan Breukink and Ben de Kruijff
doi:10.1038/nrd2004
Nature Reviews Drug Discovery 5, 321-323 (2006) FREE ACCESS
Designer probiotics for prevention of enteric infections
Adrienne W. Paton, Renato Morona and James C. Paton
doi:10.1038/nrmicro1349
Nature Reviews Microbiology 4, 193-200 (2006)
Antimicrobial-resistant bacteria in the community setting
E. Yoko Furuya and Franklin D. Lowy
doi:10.1038/nrmicro1325
Nature Reviews Microbiology 4, 36-45 (2006)
The bacterial ribosome as a target for antibiotics
Jacob Poehlsgaard and Stephen Douthwaite
doi:10.1038/nrmicro1265
Nature Reviews Microbiology 3, 870-881 (2005)
Regulation and biosynthesis of carbapenem antibiotics in bacteria
Sarah J. Coulthurst, Anne M. L. Barnard and George P. C. Salmond
doi:10.1038/nrmicro1128
Nature Reviews Microbiology 3, 295-306 (2005)
The evolving role of natural products in drug discovery
Frank E. Koehn and Guy T. Carter
doi:10.1038/nrd1657
Nature Reviews Drug Discovery 4, 206-220 (2005)
Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
Kim A. Brogden
doi:10.1038/nrmicro1098
Nature Reviews Microbiology 3, 238-250 (2005) FREE ACCESS
Antibacterial resistance worldwide: causes, challenges and responses
Stuart B Levy and Bonnie Marshall
doi:10.1038/nm1145
Nature Medicine 10, S122-S129 (2004) FREE ACCESS
Antitoxins: novel strategies to target agents of bioterrorism
G. Jonah A. Rainey and John A. T. Young
doi:10.1038/nrmicro977
Nature Reviews Microbiology 2, 721-726 (2004)
Antimicrobial pharmacodynamics: critical interactions of 'bug and drug'
George L. Drusano
doi:10.1038/nrmicro862
Nature Reviews Microbiology 2, 289-300 (2004)
Defensins: antimicrobial peptides of innate immunity
Tomas Ganz
doi:10.1038/nri1180
Nature Reviews Immunology 3, 710-720 (2003) FREE ACCESS
Genetic strategies for antibacterial drug discovery
Lynn Miesel, Jonathan Greene and Todd A. Black
doi:10.1038/nrg1086
Nature Reviews Genetics 4, 442-456 (2003) FREE ACCESS
Exploiting genomics, genetics and chemistry to combat antibiotic resistance
Diarmaid Hughes
doi:10.1038/nrg1084
Nature Reviews Genetics 4, 432-441 (2003) FREE ACCESS
Mice, microbes and models of infection
Jan Buer and Rudi Balling
doi:10.1038/nrg1019
Nature Reviews Genetics 4, 195-205 (2003) FREE ACCESS
Understanding biofilm resistance to antibacterial agents
David Davies
doi:10.1038/nrd1008
Nature Reviews Drug Discovery 2, 114-122 (2003)
Think like a bacterium
Susan S. Golden
doi:10.1038/sj.embor.embor702
EMBO Reports 4, 15-17 (2003)
The future challenges facing the development of new antimicrobial drugs
Anthony Coates, Yanmin Hu, Richard Bax and Clive Page
doi:10.1038/nrd940
Nature Reviews Drug Discovery 1, 895-910 (2002) FREE ACCESS
Chronic bacterial infections: living with unwanted guests
Douglas Young, Tracy Hussell and Gordon Dougan
doi:10.1038/ni1102-1026
Nature Immunology 3, 1026-1032 (2002) FREE ACCESS
New approaches towards the identification of antibiotic and vaccine targets in Streptococcus pneumoniae
Anne Marie Di Guilmi and Andréa Dessen
doi:10.1093/embo-reports/kvf152
EMBO Reports 3, 728-734 (2002) FREE ACCESS
Antimicrobial peptides of multicellular organisms
Michael Zasloff
doi:10.1038/415389a
Nature 415, 389-395 (2002)
Perspectives & Commentaries
Multidrug-resistance efflux pumps — not just for resistance
Laura J. V. Piddock
doi:10.1038/nrmicro1464
Nature Reviews Microbiology 4, 629-636 (2006)
Non-inherited antibiotic resistance
Bruce R. Levin and Daniel E. Rozen
doi:10.1038/nrmicro1445
Nature Reviews Microbiology 7, 556-562 (2006) FREE ACCESS
Anti-infective monoclonal antibodies: perils and promise of development
Janice M. Reichert and Matthew C. Dewitz
doi:10.1038/nrd1987
Nature Reviews Drug Discovery 5, 191-195 (2006)
The profit problem in antibiotic R&D
Carl Nathan and Frederick M. Goldberg
doi:10.1038/nrd1878
Nature Reviews Drug Discovery 4, 887-891 (2005) FREE ACCESS
Do physiological roles foster persistence of drug/multidrug-efflux transporters? A case study
Terry A. Krulwich, Oded Lewinson, Etana Padan and Eitan Bibi
doi:10.1038/nrmicro1181
Nature Reviews Microbiology 3, 566-572 (2005)
Research on infectious diseases requires better coordination
Robert G Ridley
doi:10.1038/nm1153
Nature Medicine 10, S137-S140 (2004)
Seeing is believing: the impact of structural genomics on antimicrobial drug discovery
Molly B. Schmid
doi:10.1038/nrmicro978
Nature Reviews Microbiology 2, 739-746 (2004)
Can innate immunity be enhanced to treat microbial infections?
B. Brett Finlay and Robert E. W. Hancock
doi:10.1038/nrmicro908
Nature Reviews Microbiology 2, 497-504 (2004)
Predicting the evolution of antibiotic resistance genes
Barry G. Hall
doi:10.1038/nrmicro888
Nature Reviews Microbiology 2, 430-435 (2004) FREE ACCESS
Confronting bacterial resistance in healthcare settings: a crucial role for microbiologists
John E. McGowan, Jr and Fred C. Tenover
doi:10.1038/nrmicro845
Nature Reviews Microbiology 2, 251-258 (2004)
Population and evolutionary dynamics of phage therapy
Bruce R. Levin and James J. Bull
doi:10.1038/nrmicro822
Nature Reviews Microbiology 2, 166-173 (2006)
Can better prescribing turn the tide of resistance?
David Livermore
doi:10.1038/nrmicro798
Nature Reviews Microbiology 2, 73-78 (2004)
Metabolic engineering for drug discovery and development
Chaitan Khosla and Jay D. Keasling
doi:10.1038/nrd1256
Nature Reviews Drug Discovery 2, 1019-1025 (2003)
Where will new antibiotics come from?
Christopher Walsh
doi:10.1038/nrmicro727
Nature Reviews Microbiology 1, 65-70 (2003)
