Mechanisms of cell migration
by John D. Hood and David Cheresh
Role of Integrins in cell invasion and migration, Nature Reviews Cancer 4, 255-256 (2003), doi:10.1038/nrc727
 
Cell migration is an important part of blood vessel formation, and can be viewed as a series of discrete processes that result in net cell-body movement. Initially, cells take on a polarized phenotype with a distinct cell front and rear. At the leading edge of the cell, actin polymerization and localized decreases in cell-membrane tension lead to the projection of a lamellipodium. This is seen in Hep3 adenocarcinoma cells, which respond to insulin stimulation by becoming polarized and extending lamellipodia towards the chemotactic gradient.