Case Series
Eye advance online publication 23 October 2009; doi: 10.1038/eye.2009.234
Uveitis-like syndrome and iris transillumination after the use of oral moxifloxacin
The first patient is shown as a case report poster at the Conference of the Dutch Ophthalmological Society in 2004
M Wefers Bettink-Remeijer1,4, K Brouwers2,4, L van Langenhove2, P W T De Waard1, T O Missotten1, J P Martinez Ciriano1 and E Van Aken3
- 1Het Oogziekenhuis Rotterdam, Rotterdam Eye Hospital, Schiedamse Vest 180, Rotterdam, The Netherlands
- 2Department of Ophthalmology, University Hospital Brussels, Brussel, Belgium
- 3Department of Ophthalmology, Service of Medical Retina and Vitreoretinal Surgery, University Hospital of Ghent, Ghent, Belgium
Correspondence: M Wefers Bettink-Remeijer, Department of Ophthalmology, Het Oogziekenhuis Rotterdam, Schiedamse Vest 180, Postbus 70030, Rotterdam 3011 BH, The Netherlands. Tel: +31 10 4017777; E-mail: m.wefers@oogziekenhuis.nl
4These authors contributed equally to this work
Received 20 April 2009; Revised 25 August 2009; Accepted 25 August 2009; Published online 23 October 2009.
Abstract
Objective
To report a newly recognized adverse effect of oral moxifloxacin.
Design
Observational case reports.
Participants
Five patients who used oral moxifloxacin therapy.
Main outcome measures
In five patients, a uveitis-like episode followed oral moxifloxacin therapy, afterwards they experienced photophobia. At slitlamp investigation, the patients showed almost complete iris transillumination, not restricted to one sector, and persistent mydriasis of the pupil, with no reaction to light and no near reflex. Follow-up of 3 years in one of the patients showed no change of symptoms. Only in one patient, with a history of anterior uveitis, an anterior chamber tap was positive for herpes simplex genome. Only after the use of moxifloxacin did she experience continuous photophobia.
Conclusions
Iris transillumination and sphincter paralysis is a newly recognized adverse effect of oral moxifloxacin therapy.
Keywords:
moxifloxacin, uveitis, iris transillumination, sphincter paralysis, adverse effect
