Clinical Study
Eye advance online publication 9 May 2008; doi: 10.1038/eye.2008.114
Orbital floor triamcinolone acetonide injections for the management of active non-infectious uveitis
The authors have no financial interest in any of the reagents used in this study
M Roesel1, M Gutfleisch1, C Heinz1, B Heimes1, B Zurek-Imhoff1 and A Heiligenhaus1
1Department of Ophthalmology, St Franziskus Hospital, University Duisburg-Essen, Muenster, Germany
Correspondence: A Heiligenhaus, Department of Ophthalmology, St Franziskus Hospital, University Duisburg-Essen, Hohenzollernring 74, Muenster 48145, Germany. Tel: +49 0251 933080; Fax: +49 0251 9330819; E-mail: arnd.heiligenhaus@uveitis-zentrum.de
Received 23 November 2007; Revised 25 March 2008; Accepted 25 March 2008; Published online 9 May 2008.
Abstract
Purpose
To evaluate the effect of orbital floor triamcinolone acetonide (OFTA) injections on inflammation and visual acuity in active non-infectious uveitis.
Methods
Monocentre, retrospective study in 94 eyes (86 patients) with acute non-infectious uveitis receiving a single OFTA (40 mg) injection. Outcome measures were anterior chamber (AC) and vitreous cell counts, laser flare photometry, best-corrected visual acuity (BCVA), and complications over a 6-month follow-up period.
Results
The number of patients with 
1+ cells in AC and vitreous was significantly lower after treatment than at baseline (each, P<0.01 at the follow-up examinations). The anti-inflammatory effect lasted for the 6-month follow-up period. Laser flare photometry values were also significantly lower than the baseline levels at 3 (P<0.01) and 6 (P=0.034) months. BCVA did not differ before and after treatment. Macular oedema was reduced in 27%
, unchanged in another 59%
, and worse in 14%
. Within 6 months, ocular hypertension was observed in up to 8%
and progressing cataract was noted in 29%
.
Conclusions
OFTA injections improved AC and vitreous inflammation, but the effect on visual acuity and macular oedema was limited.
Keywords:
uveitis, triamcinolone, orbital floor, intravitreal, inflammation
