Review
Eye (2009) 23, 1269–1274; doi:10.1038/eye.2009.30; published online 20 February 2009
Ocular teratogens: old acquaintances and new dangers
- 1Department of Ophthalmology, Kettering General Hospital, Edinburgh, UK
- 2Princess Alexandra Eye Pavilion, Edinburgh, UK
Correspondence: A Tandon, Ophthalmology, Kettering General Hospital, Rothwell Road, Kettering, Northants NN16 8UZ, UK. Tel: +44 131 536 1674; Fax: +44 131 536 1574; E-mail: anamikatan@gmail.com
Received 27 September 2007; Revised 22 January 2009; Accepted 22 January 2009; Published online 20 February 2009.
Abstract
Recent research into animal studies has contributed significantly to understanding the pathophysiology of some well-known teratogens, such as alcohol. Techniques, such as positron emission tomography (PET) and retinal synaptogenesis studies, have helped determine the specific areas in the developing brain and ocular structures, which are targeted by various teratogens. In this article, we also highlight a few newer agents, such as benzodiazepines, with potential for ocular malformation and morbidity in the developing foetus.
Keywords:
Teratogen, Embryology, PAX6, Fetal alcohol syndrome, Retinal synaptogenesis, Neurotropic
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