Clinical Study
Eye (2009) 23, 626–631; doi:10.1038/eye.2008.28; published online 22 February 2008
Association of complement factor H and LOC387715 genotypes with response of exudative age-related macular degeneration to photodynamic therapy
M A Brantley Jr1,2, S L Edelstein1, J M King1, M R Plotzke1, R S Apte1,2, S M Kymes1 and A Shiels1
- 1Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO, USA
- 2Barnes Retina Institute, 1600 S. Brentwood Blvd., Suite 800, St Louis, MO, USA
Correspondence: MA Brantley Jr, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, 660 S Euclid Avenue, Campus Box 8096, St Louis, MO 63110, USA Tel: +314 747 5606; Fax: +314 747 4121; E-mail: brantley@vision.wustl.edu
Received 3 August 2007; Accepted 21 January 2008; Published online 22 February 2008.
Abstract
Aim
To determine whether there is an association between complement factor H (CFH) or LOC387715 genotypes and response to treatment with photodynamic therapy (PDT) for exudative age-related macular degeneration (AMD).
Methods
Sixty-nine patients being treated for neovascular AMD with PDT were genotyped for the CFH Y402H and LOC387715 A69S polymorphisms by allele-specific digestion of PCR products. AMD phenotypes were characterized by clinical examination, fundus photography, and fluorescein angiography.
Results
Adjusting for age, pre-PDT visual acuity (VA), and lesion type, mean VA after PDT was significantly worse for the CFH TT genotype than for the TC or CC genotypes (P=0.05). Post-PDT VA was significantly worse for the CFH TT genotype in the subgroup of patients with predominantly classic choroidal neovascular lesions (P=0.04), but not for the patients with occult lesions (P=0.22). For the LOC387715 A69S variant, there was no significant difference among the genotypes in response to PDT therapy.
Conclusions
The CFH Y402H variant was associated with a response to PDT treatment in this study. Patients with the CFH TT genotype fared significantly worse with PDT than did those with the CFH TC and CC genotypes, suggesting a potential relationship between CFH genotype and response to PDT.
Keywords:
AMD, CFH, LOC387715, photodynamic
